{PDOC51764}
{PS51764; GH26}
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* Glycosyl hydrolases family 26 (GH26) domain profile *
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Glycoside hydrolases  (GHs)  play  a  critical  role  in  both  eukaryotes and
prokaryotes, where they fulfill numerous important functions such as substrate
acquisition and   the   remote  remodelling  of  cell  walls  and  the  glycan
decorations of  glycoproteins.  GH family 26 consists mainly of endo-beta-1,4-
mannanases (mannanases),  although  some  members of this family display beta-
1,3-xylanase activity.   The   family   26   GHs  are  members  of  clan  GH-A
[1,2,3,4,E1].

The GH26   catalytic   domain  exhibits  the  architecture  of  the  classical
(beta/alpha)8-barrel folding   motif  characteristic  of  a  clan-GH-A  member
(see <PDB:2BVY>).  Two Glu residues located respectively on strands beta-4 and
beta-7 act as the catalytic acid/base and nucleophile in a double-displacement
mechanism [1,2,3].

The profile we developed covers the entire GH26 domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: July 2015 / First entry.

[ 1] Hogg D., Woo E.-J., Bolam D.N., McKie V.A., Gilbert H.J.,
     Pickersgill R.W.
     "Crystal structure of mannanase 26A from Pseudomonas cellulosa and
     analysis of residues involved in substrate binding."
     J. Biol. Chem. 276:31186-31192(2001).
     PubMed=11382747; DOI=10.1074/jbc.M010290200
[ 2] Le Nours J., Anderson L., Stoll D., Stalbrand H., Lo Leggio L.
     "The structure and characterization of a modular
     endo-beta-1,4-mannanase from Cellulomonas fimi."
     Biochemistry 44:12700-12708(2005).
     PubMed=16171384; DOI=10.1021/bi050779v
[ 3] Taylor E.J., Goyal A., Guerreiro C.I.P.D., Prates J.A.M., Money V.A.,
     Ferry N., Morland C., Planas A., Macdonald J.A., Stick R.V.,
     Gilbert H.J., Fontes C.M.J.A., Davies G.J.
     "How family 26 glycoside hydrolases orchestrate catalysis on different
     polysaccharides: structure and activity of a Clostridium thermocellum
     lichenase,  CtLic26A."
     J. Biol. Chem. 280:32761-32767(2005).
     PubMed=15987675; DOI=10.1074/jbc.M506580200
[ 4] Fu X., Huang X., Liu P., Lin L., Wu G., Li C., Feng C., Hong Y.
     "Cloning and characterization of a novel mannanase from Paenibacillus
     sp. BME-14."
     J. Microbiol. Biotechnol. 20:518-524(2010).
     PubMed=20372022
[E1] http://www.cazy.org/GH26.html

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