{PDOC51773}
{PS51773; OCP_N}
{BEGIN}
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* Orange carotenoid protein (OCP) N-terminal domain profile *
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The photoprotective   processes   of   photosynthetic  organisms  involve  the
dissipation of  excess  absorbed  light  energy  as  heat.  Photoprotection in
cyanobacteria is mechanistically distinct from that in plants; it involves the
orange carotenoid  protein  (OCP), a water soluble protein containing a single
carotenoid. The  OCP  serves as a sensor of light intensity and an effector of
phycobilisome (PB)-associated  photoprotection in cyanobacteria. Structurally,
the OCP  is  composed  of  two distinct domains spanned by a single carotenoid
chromophore. The  OCP  C-terminal  is  suggested  to  dynamically regulate the
photoprotective activity on otherwise constitutively active carotenoid binding
N-terminal domain [1,2,3].

The all-helical  OCP  N-terminal  domain  can  be  divided into two four-helix
bundles (see <PDB:1M98>) [1,2,3].

The profile we developed covers the entire OCP N-terminal domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: August 2015 / First entry.

[ 1] Kerfeld C.A., Sawaya M.R., Brahmandam V., Cascio D., Ho K.K.,
     Trevithick-Sutton C.C., Krogmann D.W., Yeates T.O.
     "The crystal structure of a cyanobacterial water-soluble carotenoid
     binding protein."
     Structure 11:55-65(2003).
     PubMed=12517340
[ 2] Wilson A., Kinney J.N., Zwart P.H., Punginelli C., D'Haene S.,
     Perreau F., Klein M.G., Kirilovsky D., Kerfeld C.A.
     "Structural determinants underlying photoprotection in the photoactive
     orange carotenoid protein of cyanobacteria."
     J. Biol. Chem. 285:18364-18375(2010).
     PubMed=20368334; DOI=10.1074/jbc.M110.115709
[ 3] Leverenz R.L., Jallet D., Li M.-D., Mathies R.A., Kirilovsky D.,
     Kerfeld C.A.
     "Structural and functional modularity of the orange carotenoid
     protein: distinct roles for the N- and C-terminal domains in
     cyanobacterial photoprotection."
     Plant Cell 26:426-437(2014).
     PubMed=24399299; DOI=10.1105/tpc.113.118588

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