{PDOC51774}
{PS51774; NAB}
{BEGIN}
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* Networked (NET) actin-binding (NAB) domain profile *
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The Networked (NET) proteins are a superfamily of plant-specific actin-binding
proteins which  localize simultaneously to the actin cytoskeleton and specific
membrane compartments and are suggested to couple these membranes to the actin
cytoskeleton in  plant cells. The minimal actin binding region, referred to as
the NET  actin-binding  (NAB)  domain,  represents  a  new actin binding motif
unique to  plants  with  no  apparent  primary  sequence homolgy to previously
identified actin binding domains. In Arabidopsis, the NAB domain always starts
with three  conserved  tryptophan  residues,  WWW, a motif whose worldwide web
connection gives  added  significance  to  the NET family name. The C terminal
half of  the  domain  is  very  highly  conserved, more so than the N terminal
[1,2].

The predicted  secondary  structure  of  the domain includes three major alpha
helices connected  by a beta turns with the WWW motif predicted to form a beta
sheet [1,2].

The profile we developed covers the entire NAB domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: September 2015 / First entry.

[ 1] Deeks M.J., Calcutt J.R., Ingle E.K.S., Hawkins T.J., Chapman S.,
     Richardson A.C., Mentlak D.A., Dixon M.R., Cartwright F.,
     Smertenko A.P., Oparka K., Hussey P.J.
     "A superfamily of actin-binding proteins at the actin-membrane nexus
     of higher plants."
     Curr. Biol. 22:1595-1600(2012).
     PubMed=22840520; DOI=10.1016/j.cub.2012.06.041
[ 2] Hawkins T.J., Deeks M.J., Wang P., Hussey P.J.
     "The evolution of the actin binding NET superfamily."
     Front. Plant Sci. 5:254-254(2014).
     PubMed=24926301; DOI=10.3389/fpls.2014.00254

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