{PDOC51775}
{PS51775; GTD_BINDING}
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* GTD-binding domain profile *
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The GTD-binding domain is a plant-specific protein-protein interaction domain.
It emerged  in  primitive  land  plants and founded a multigene family that is
conserved in all flowering plants. Proteins with GTD-binding domains fall into
four groups,  where group 1-3 contain the GTD-binding domain at the C-terminal
half of the protein and one (group 2) or more (group1) predicted transmembrane
domains, or  an  endoplasmic  reticulum  signal  peptide  (group  3) at the N-
terminus, whereas group 4 contains the GTD-binding domain near the N-terminus.
GTD-binding domain proteins may constitute a family of myosin receptors, which
are associated  with  the  surface  of  specific plant organelles, bind to the
globular tail  domain  (GTD)  of  myosin  motor  proteins, and thereby promote
actin-dependent organelle  motility.  It seems likely that myosin binding is a
common property  of  the GTD-binding domain, whereas the ability of FLOURY1 to
bind maize-specific  zeins is a specific feature of this endoplasmic reticulum
(ER)-associated protein.

The GTD-binding domain is predicted to adopt a coiled-coil structure.

Some proteins known to contain a GTD-binding domain are listed below:

 - Maize  FLOURY1  (FL1),  which  belongs  to  group 1. Its GTD-binding domain
   facilitates the localization of 22-kD alpha-zein [1].
 - Arabidopsis  myosin  binding  (MyoB)  proteins  1-6  and  7,  which  belong
   respectively to group 3 and 4. They bind to myosin XI [2].
 - Tobacco  RAC5  interacting  subapical  pollen  tube  protein (RISAP), which
   belongs to  group  3. It binds via its GTD-binding domain to the GTD domain
   of a pollen tube myosin XI [3].
 - Lily  LLP13,  which belongs to group 3. It is likely a cytoskeleton-binding
   protein that binds with intermediate filaments (IFs) that potentially exist
   in pollen tubes [4].

The profile we developed covers the entire GTD-binding domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: September 2015 / First entry.

[ 1] Holding D.R., Otegui M.S., Li B., Meeley R.B., Dam T., Hunter B.G.,
     Jung R., Larkins B.A.
     "The maize floury1 gene encodes a novel endoplasmic reticulum protein
     involved in  zein protein body formation."
     Plant Cell 19:2569-2582(2007).
     PubMed=17693529; DOI=10.1105/tpc.107.053538
[ 2] Peremyslov V.V., Morgun E.A., Kurth E.G., Makarova K.S., Koonin E.V.,
     Dolja V.V.
     "Identification of myosin XI receptors in Arabidopsis defines a
     distinct class of  transport vesicles."
     Plant Cell 25:3022-3038(2013).
     PubMed=23995081; DOI=10.1105/tpc.113.113704
[ 3] Stephan O., Cottier S., Fahlen S., Montes-Rodriguez A., Sun J.,
     Eklund D.M., Klahre U., Kost B.
     "RISAP is a TGN-associated RAC5 effector regulating membrane traffic
     during polar  cell growth in tobacco."
     Plant Cell 26:4426-4447(2014).
     PubMed=25387880; DOI=10.1105/tpc.114.131078
[ 4] Wang B.-J., Hsu Y.-F., Chen Y.-C., Wang C.-S.
     "Characterization of a lily anther-specific gene encoding
     cytoskeleton-binding glycoproteins and overexpression of the gene
     causes severe inhibition of pollen tube growth."
     Planta 240:525-537(2014).
     PubMed=24944111; DOI=10.1007/s00425-014-2099-x

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