{PDOC51777}
{PS51777; RH2}
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* RH2 domain profile *
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The RH2  (RILP homology 2) Rab-binding domain is found in the following animal
proteins [1,2,3]:

 - Rab  interacting  lysosomal  proteins  (RILP),  which  interacts with Rab7,
   Rab34, and Rab36.
 - RILP-like 1 (RILP-L1), which interacts with Rab12, Rab34, and Rab36.
 - RILP-like 2 (RILP-L2), which interacts with Rab34 and Rab36.
 - JNK-interacting protein 3 (JIP3), which interacts with Rab36 alone.
 - JNK-interacting protein 4 (JIP4), which interacts with Rab36 alone.

The RH2  domain  is  folded  into a long helix alpha1 and a short helix alpha2
connected by  a  very  tight  loop  (see  <PDB:1YHN>).  The RH2 domain forms a
tightly associated  four  helices  homodimer  in which both helices alpha1 and
alpha2 are  involved  in  dimerization. Such a homodimer binds to two separate
Rab-GTP molecules  on  opposite  sides,  with  both  helices  involved  in the
interaction with   Rab.  In  the  complex  interface,  although  each  Rab-GTP
interacts with  both  helices  of  the  RH2  domain,  these  two  helices  are
contributed by  two  different  molecules,  with  helix alpha1 coming from one
protomer and helix alpha2 from the other protomer [2].

The profile we developed covers the entire RH2 domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: October 2015 / First entry.

[ 1] Wang T., Wong K.K., Hong W.
     "A unique region of RILP distinguishes it from its related proteins in
     its regulation of lysosomal morphology and interaction with Rab7 and
     Rab34."
     Mol. Biol. Cell 15:815-826(2004).
     PubMed=14668488; DOI=10.1091/mbc.E03-06-0413
[ 2] Wu M., Wang T., Loh E., Hong W., Song H.
     "Structural basis for recruitment of RILP by small GTPase Rab7."
     EMBO J. 24:1491-1501(2005).
     PubMed=15933719; DOI=10.1038/sj.emboj.7600643
[ 3] Matsui T., Ohbayashi N., Fukuda M.
     "The Rab interacting lysosomal protein (RILP) homology domain
     functions as a novel effector domain for small GTPase Rab36: Rab36
     regulates retrograde melanosome transport in melanocytes."
     J. Biol. Chem. 287:28619-28631(2012).
     PubMed=22740695; DOI=10.1074/jbc.M112.370544

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