{PDOC51781} {PS51781; SH3B} {BEGIN} *********************** * SH3b domain profile * *********************** Src homology 3 (SH3) domains (see ) are widespread among metazoan intracellular signalling proteins and typically bind proline-rich polypeptides. The SH3b domain is a prokaryotic homologue. The SH3b domain might have two possible functions: (1) promoting survival of a pathogen within the invaded cell by modulating pathways controlled by SH3 domains; or (2) promoting invasion by binding to receptors on eukaryotic cells [1,2]. Some proteins known to contain a SH3b domain are listed below: - Listeria invasion-associated protein p60, a probable endopeptidase. - Staphylococcus simulans lysostaphin. - Bacillus subtilis beta-N-acetylglucosaminidase lytD. - Bacillus subtilis uncharacterized protein YfhK. - Synechocystis sp. serine/threonine-protein kinase D (spkD). The profile we developed covers the entire SH3b domain. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: October 2017 / Profile revised. [ 1] Whisstock J.C., Lesk A.M. "SH3 domains in prokaryotes." Trends Biochem. Sci. 24:132-133(1999). PubMed=10322416 [ 2] Ponting C.P., Aravind L., Schultz J., Bork P., Koonin E.V. "Eukaryotic signalling domain homologues in archaea and bacteria. Ancient ancestry and horizontal gene transfer." J. Mol. Biol. 289:729-745(1999). PubMed=10369758; DOI=10.1006/jmbi.1999.2827 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}