{PDOC51791}
{PS51791; HSAC2}
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* hSac2 domain profile *
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Sac2 is  an  evolutionarily  conserved protein in multicellular organisms from
nematode to  human.  Sac2  orthologues  are also found in fungi genera such as
Aspergillus species  and  Yarrowia  lipolytica, but is absent in Saccharomyces
cerevisiae. Sac2   is   a   phosphatidylinositol   (PI)   4-phosphatase   that
specifically hydrolyzes    phosphatidylinositol    4-phosphate   (PI(4)P)   to
phosphatidylinositol. Besides   the  conserved  N-terminal  Sac1  domain  (see
<PDOC00978>), Sac2  contains  a unique homology domain, homology Sac2 (hSac2),
followed by   a  proline-rich  C-terminal  portion  with  various  lengths  in
different species.  The  hSac2  domain  plays  a role in Sac2 dimerization and
intracellular localization. The hSac2 domain is also found in proteins encoded
by the  transformation-related  protein  63  regulated 1 (TPRG1) and the tumor
protein p63 regulated gene 1-like genes (TPRGl) [1,2,3,4].

The hSac2 domain has a PH domain-like (see <PDOC50003>) fold and consists of a
core of  two perpendicularly apposed beta sheets with a C-terminal alpha helix
that seals  the gap between the two sheets. In addition to the core, hSac2 has
an extra  N-terminal alpha helix and a short beta strand in the C-terminal end
(see <PDB:4XUU>) [1].

The profile we developed covers the entire hSac2 domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: February 2016 / First entry.

[ 1] Hsu F., Hu F., Mao Y.
     "Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2
     regulates endocytic recycling."
     J. Cell Biol. 209:97-110(2015).
     PubMed=25869669; DOI=10.1083/jcb.201408027
[ 2] Minagawa T., Ijuin T., Mochizuki Y., Takenawa T.
     "Identification and characterization of a sac domain-containing
     phosphoinositide 5-phosphatase."
     J. Biol. Chem. 276:22011-22015(2001).
     PubMed=11274189; DOI=10.1074/jbc.M101579200
[ 3] Antonini D., Dentice M., Mahtani P., De Rosa L., Della Gatta G.,
     Mandinova A., Salvatore D., Stupka E., Missero C.
     "Tprg, a gene predominantly expressed in skin, is a direct target of
     the transcription factor p63."
     J. Invest. Dermatol. 128:1676-1685(2008).
     PubMed=18256694; DOI=10.1038/jid.2008.12
[ 4] Kremer T., Kempf C., Wittenmayer N., Nawrotzki R., Kuner T.,
     Kirsch J., Dresbach T.
     "Mover is a novel vertebrate-specific presynaptic protein with
     differential distribution at subsets of CNS synapses."
     FEBS Lett. 581:4727-4733(2007).
     PubMed=17869247; DOI=10.1016/j.febslet.2007.08.070

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