{PDOC51792}
{PS51792; YIPPEE}
{BEGIN}
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* Yippee domain profile *
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The Yippee-like  (YPEL) family proteins share homology to drosophila Yippee, a
zinc finger  binding  protein. YPEL proteins are found in essentiallly all the
eukaryotes and  hence  they  must  play  important roles in the maintenance of
life. Subcellular  localization  of  all  YPEL proteins to the centrosomes and
the mitotic  apparatus  suggest their role in the mitosis-associated function.
YPEL proteins  contain  a Yippee domain, which is a putative zinc-finger-like,
metal-binding domain [1,2,3,4].

The Yippee  domain  contains two cysteine pairs that are fifty-two amino acids
appart (C-X(2)-C-X(52)-C-X(2)-C)  and  could be part of a metal (zinc) binding
pocket [1].

The profile we developed covers the entire Yippee domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: February 2016 / First entry.

[ 1] Roxstroem-Lindquist K., Faye I.
     "The Drosophila gene Yippee reveals a novel family of putative zinc
     binding proteins highly conserved among eukaryotes."
     Insect Mol. Biol. 10:77-86(2001).
     PubMed=11240639
[ 2] Hosono K., Sasaki T., Minoshima S., Shimizu N.
     "Identification and characterization of a novel gene family YPEL in a
     wide spectrum of eukaryotic species."
     Gene 340:31-43(2004).
     PubMed=15556292; DOI=10.1016/j.gene.2004.06.014
[ 3] Liang P., Wan Y., Yan Y., Wang Y., Luo N., Deng Y., Fan X., Zhou J.,
     Li Y., Wang Z., Yuan W., Tang M., Mo X., Wu X.
     "MVP interacts with YPEL4 and inhibits YPEL4-mediated activities of
     the ERK signal pathway."
     Biochem. Cell Biol. 88:445-450(2010).
     PubMed=20555386; DOI=10.1139/o09-166
[ 4] Tan T.Y., Gordon C.T., Miller K.A., Amor D.J., Farlie P.G.
     "YPEL1 overexpression in early avian craniofacial mesenchyme causes
     mandibular dysmorphogenesis by up-regulating apoptosis."
     Dev. Dyn. 244:1022-1030(2015).
     PubMed=26061551; DOI=10.1002/dvdy.24299

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