{PDOC51799}
{PS51799; ZF_C2H2_AKAP95}
{BEGIN}
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* Zinc finger C2H2 AKAP95-type profile *
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A-kinase (or PKA)-anchoring protein AKAP95 is a member of the AKAP-family that
binds to  regulatory  subunits  of protein kinase A (PKA) and localizes PKA to
various distinct  locations  and  structures  within  cells. AKAP95 is a zinc-
finger protein  implicated  in  mitotic chromosome condensation by acting as a
targeting molecule  for  the  condensin  complex. In addition to anchoring the
regulatory subunit  (RII)  of  cyclic adenosine monophosphate (cAMP)-dependent
protein kinase  (PKA), AKAP95 binds chromatin at mitosis. It harbours two zinc
fingers, designated  ZF1  and  ZF2. ZF1 mediates the binding of AKAP95 to DNA.
ZF2 is  dispensable  for  chromatin binding; however it may substitute for ZF1
when the latter is rendered non-functional by mutation [1,2,3].

The profile we developed covers the entire C2H2 AKAP95-type zinc finger.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: May 2016 / First entry.

[ 1] Seki N., Ueki N., Yano K., Saito T., Masuho Y., Muramatsu M.
     "cDNA cloning of a novel human gene NAKAP95, neighbor of A-kinase
     anchoring protein 95 (AKAP95) on chromosome 19p13.11-p13.12 region."
     J. Hum. Genet. 45:31-37(2000).
     PubMed=10697960; DOI=10.1007/s100380070040
[ 2] Eide T., Carlson C., Tasken K.A., Hirano T., Tasken K., Collas P.
     "Distinct but overlapping domains of AKAP95 are implicated in
     chromosome condensation and condensin targeting."
     EMBO Rep. 3:426-432(2002).
     PubMed=11964380; DOI=10.1093/embo-reports/kvf089
[ 3] Marstad A., Landsverk O.J., Stromme O., Otterlei M., Collas P.,
     Sundan A., Brede G.
     "A-kinase anchoring protein AKAP95 is a novel regulator of ribosomal
     RNA synthesis."
     FEBS J. 283:757-770(2016).
     PubMed=26683827; DOI=10.1111/febs.13630

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