{PDOC51800}
{PS51800; ZF_CHHC_U11_48K}
{BEGIN}
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* Zinc finger CHHC U11-48K-type profile *
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The CHHC  U11-48K-type  zinc  finger  is found only in eukaryotes. It has been
identified in  spliceosomal  U11-48K  proteins, tRNA methyl-transferases TRM13
and gametocyte specific factors (GTSF). The CHHC U11-48K-type zinc finger (~30
residues) is  present  in  a  single  copy  in U11-48k AND TRM13, whereas GTSF
contains two  repeats  separated by a short linker. The CHHC U11-48K-type zinc
finger may function as a RNA recognition and binding module [1,2].

The CHHC U11-48K-type zinc finger contains four invariant Cys and His residues
with a     consensus     sequence    of    C-x(5,7)-H-x(7,9)-H-x(3,4)-C.    It
stochiometrically binds  zinc ions in a one-to-one ratio. The structure of the
CHHC U11-48K-type  zinc  finger consists of a beta hairpin followed by a helix
(see <PDB:2VY4>). the zinc ion is coordinated by Cys and His residues from the
beta hairpin  and  by  His  and Cys residues from the helix, respectively. The
helical region  has  an  alpha-helical conformation that is interrupted in the
middle by a single pi-helical turn [2].

The profile we developed covers the entire CHHC U11-48K-type zinc finger.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: May 2016 / First entry.

[ 1] Andreeva A., Tidow H.
     "A novel CHHC Zn-finger domain found in spliceosomal proteins and tRNA
     modifying enzymes."
     Bioinformatics 24:2277-2280(2008).
     PubMed=18703587; DOI=10.1093/bioinformatics/btn431
[ 2] Tidow H., Andreeva A., Rutherford T.J., Fersht A.R.
     "Solution structure of the U11-48K CHHC zinc-finger domain that
     specifically binds the 5' splice site of U12-type introns."
     Structure 17:294-302(2009).
     PubMed=19217400; DOI=10.1016/j.str.2008.11.013

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