{PDOC51801}
{PS51801; ZF_CCHC_NOA}
{BEGIN}
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* Zinc finger CCHC NOA-type profile *
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The regulatory NEMO (NF-kappaB essential modulator) protein has a crucial role
in the  canonical  NF-kappaB  signaling pathway notably involved in immune and
inflammatory responses,  apoptosis  and  oncogenesis. The regulatory domain is
located in  the  C-terminal  half of NEMO and contains a CCHC-type zinc finger
(ZF). A similar CCHC-type zinc finger is also found in other regulators of NF-
kappaB, such  as  Optineurin  and ABIN2. The CCHC NOA (NEMO Optineurin ABIN2)-
type zinc  finger  has  been  shown to function as an ubiquitin-binding domain
(UBD) [1,2].

The CCHC  NOA-type  zinc  finger  consists of a short antiparallel beta-sheet,
where beta1  and  beta2  strands  are connected by a type IV beta-turn, and an
alpha-helix (see   <PDB:2JVX>).  This  BetaBetaAlpha  fold  is  stabilized  by
tetrahedral coordination to a zinc ion [1].

The profile we developed covers the entire CCHC NOA-type zinc finger.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: June 2016 / First entry.

[ 1] Cordier F., Vinolo E., Veron M., Delepierre M., Agou F.
     "Solution structure of NEMO zinc finger and impact of an anhidrotic
     ectodermal dysplasia with immunodeficiency-related point mutation."
     J. Mol. Biol. 377:1419-1432(2008).
     PubMed=18313693; DOI=10.1016/j.jmb.2008.01.048
[ 2] Laplantine E., Fontan E., Chiaravalli J., Lopez T., Lakisic G.,
     Veron M., Agou F., Israel A.
     "NEMO specifically recognizes K63-linked poly-ubiquitin chains through
     a new bipartite ubiquitin-binding domain."
     EMBO J. 28:2885-2895(2009).
     PubMed=19763089; DOI=10.1038/emboj.2009.241

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