{PDOC51806}
{PS51806; DOG1}
{BEGIN}
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* DOG1 domain profile *
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The DELAY  OF  GERMINATION1  (DOG1)  protein  is  a positive regulator for the
establishment and  maintenance  of  primary  seed  dormancy in plants. DOG1 is
involved in   transducing   maternal   environmental  conditions  during  seed
development into  effects on seed dormancy and in the loss of dormancy through
dry after-ripening  or  moist  chilling.  DOG1  belongs  to  a small family of
proteins that  can  be  classified  into five distinct clades (1-5). Of these,
DOG1-like proteins  in clades 1-4 have a similar architecture to DOG1, sharing
the same  domain.  In contrast, the clade 5 proteins are distinct: they harbor
an additional bZIP domain (see <PDOC00036>), that interacts with DNA, and play
a major  role in disease resistance and development. The DOG1 domain is formed
by Glutamine  rich  regions QI and QII and acidic amino acids and is likely to
be a transcriptional activation domain [1,2,3,4,5].

Some proteins known to contain a DOG1 domain are listed below:

 - Arabidopsis thaliana DOG1, functions in seed dormancy and sugar signalling.
 - Arabidopsis  thaliana  PERIANTHIA  (PAN),  a  bZIP  protein involved in the
   determination of floral organ number.
 - Arabidopsis   thaliana   TGA1,   a  transcriptional  activator  that  binds
   specifically to the DNA sequence 5'-TGACG-3'.
 - Tobacco  TGA1a,  a transcriptional activator that binds specifically to the
   DNA sequence 5'-TGACG-3'.
 - Wheat  HBP-1b  protein, a transcriptional activator that binds specifically
   to the DNA sequence 5'-TGACG-3'.

The profile we developed covers the entire DOG1 domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: July 2016 / First entry.

[ 1] Chuang C.F., Running M.P., Williams R.W., Meyerowitz E.M.
     "The PERIANTHIA gene encodes a bZIP protein involved in the
     determination of floral organ number in Arabidopsis thaliana."
     Genes Dev. 13:334-344(1999).
     PubMed=9990857
[ 2] Bentsink L., Jowett J., Hanhart C.J., Koornneef M.
     "Cloning of DOG1, a quantitative trait locus controlling seed dormancy
     in Arabidopsis."
     Proc. Natl. Acad. Sci. U.S.A. 103:17042-17047(2006).
     PubMed=17065317; DOI=10.1073/pnas.0607877103
[ 3] Idrovo Espin F.M., Peraza-Echeverria S., Fuentes G., Santamaria J.M.
     "In silico cloning and characterization of the TGA (TGACG
     MOTIF-BINDING FACTOR) transcription factors subfamily in Carica
     papaya."
     Plant Physiol. Biochem. 54:113-122(2012).
     PubMed=22410205; DOI=10.1016/j.plaphy.2012.02.011
[ 4] Ashikawa I., Abe F., Nakamura S.
     "DOG1-like genes in cereals: investigation of their function by means
     of ectopic expression in Arabidopsis."
     Plant Sci. 208:1-9(2013).
     PubMed=23683923; DOI=10.1016/j.plantsci.2013.03.011
[ 5] Huo H., Wei S., Bradford K.J.
     "DELAY OF GERMINATION1 (DOG1) regulates both seed dormancy and
     flowering time through microRNA pathways."
     Proc. Natl. Acad. Sci. U.S.A. 113:E2199-E2206(2016).
     PubMed=27035986; DOI=10.1073/pnas.1600558113

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