{PDOC51817} {PS51817; PEPTIDASE_A3B} {BEGIN} *************************************** * Peptidase family A3B domain profile * *************************************** Rice tungro bacilliform virus (RTBV) is a pararetrovirus, and a member of the family Caulimoviridae in the genus Tungrovirus [E1]. RTBV has a long open reading frame that encodes a large polyprotein (P3). P3 contains a putative movement protein (MP), the capsid protein (CP), the aspartate protease (PR) and the reverse transcriptase (RT) with a ribonuclease H activity. PR is a member of the cluster of retroviral proteases and serves to proteolytically process P3. The sequence DSGS is believed to be the RTBV protease active site [1]. The RTBV PR domain forms peptidase family A3 subfamily B [E2]. The profile we developed covers the entire peptidase family A3B domain. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: September 2016 / First entry. [ 1] Marmey P., Rojas-Mendoza A., de Kochko A., Beachy R.N., Fauquet C.M. "Characterization of the protease domain of Rice tungro bacilliform virus responsible for the processing of the capsid protein from the polyprotein." Virol. J. 2:33-33(2005). PubMed=15831103; DOI=10.1186/1743-422X-2-33 [E1] https://viralzone.expasy.org/124?outline=all_by_species [E2] https://www.ebi.ac.uk/merops/cgi-bin/famsum?family=A3 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}