{PDOC51823}
{PS51823; CLU}
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* Clueless (Clu) domain profile *
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The protein  Clueless  (Clu)  is  a  large multi-domain protein that is highly
conserved and directly required for mitochondrial function. Clu is involved in
binding and  directing  nuclear  encoded mitochondrially destined mRNAs to the
mitochondrial outer   membrane   and  potentially  positioning  them  for  co-
translational import.  Clu  may  act  as  a  type  of  scaffold that can bring
together several  mechanisms  in  order to maintain mitochondrial function and
output. Clu-related  proteins are highly conserved and share a ~245-amino acid
region (the 'Clu domain') and TPR repeats (see <PDOC50005>) [1,2,3].

The profile we developed covers the entire Clu domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2016 / First entry.

[ 1] Cox R.T., Spradling A.C.
     "Clueless, a conserved Drosophila gene required for mitochondrial
     subcellular localization, interacts genetically with parkin."
     Dis. Model. Mech. 2:490-499(2009).
     PubMed=19638420; DOI=10.1242/dmm.002378
[ 2] Sen A., Kalvakuri S., Bodmer R., Cox R.T.
     "Clueless, a protein required for mitochondrial function, interacts
     with the PINK1-Parkin complex in Drosophila."
     Dis. Model. Mech. 8:577-589(2015).
     PubMed=26035866; DOI=10.1242/dmm.019208
[ 3] Sen A., Cox R.T.
     "Clueless is a conserved ribonucleoprotein that binds the ribosome at
     the mitochondrial outer membrane."
     Biol. Open 5:195-203(2016).
     PubMed=26834020; DOI=10.1242/bio.015313

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