{PDOC51830}
{PS51830; FIIND}
{BEGIN}
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* FIIND domain profile *
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The "Function  to  Find  Domain"  (FIIND)-containing proteins CARD8 (Cardinal;
Tucan) and  NLRP1  (NALP1;  NAC)  are  well known components of inflammasomes,
multiprotein complexes responsible for activation of caspase-1, a regulator of
inflammation and  innate  immunity.  CARD8  and  NLRP1 undergo autoproteolytic
cleavage at  a conserved SF/S motif within the FIIND. The FIIND domain is only
present in chordates and consists of a ZU5-like domain (see <PDOC51145>) and a
UPA-like domain [1,2,3].

The profile we developed covers the entire FIIND domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: March 2017 / First entry.

[ 1] Tschopp J., Martinon F., Burns K.
     "NALPs: a novel protein family involved in inflammation."
     Nat. Rev. Mol. Cell Biol. 4:95-104(2003).
     PubMed=12563287; DOI=10.1038/nrm1019
[ 2] D'Osualdo A., Weichenberger C.X., Wagner R.N., Godzik A., Wooley J.,
     Reed J.C.
     "CARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like
     domain."
     PLoS ONE 6:E27396-E27396(2011).
     PubMed=22087307; DOI=10.1371/journal.pone.0027396
[ 3] Liao Y., Pei J., Cheng H., Grishin N.V.
     "An ancient autoproteolytic domain found in GAIN, ZU5 and
     Nucleoporin98."
     J. Mol. Biol. 426:3935-3945(2014).
     PubMed=25451782; DOI=10.1016/j.jmb.2014.10.011

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