{PDOC51848}
{PS51848; BMERB}
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* bMERB domain profile *
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A variety  of different effector proteins interact specifically with GTP-bound
Rab proteins  and  mediate  their  versatile  roles  in  membrane trafficking,
including budding  of  vesicles  from  a  donor  membrane,  directed transport
through the  cell and finally tethering and fusion with a target membrane. The
"bivalent Mical/EHBP Rab binding" (bMERB) domain is a Rab effector domain that
is present  in  proteins  of the Mical and EHBP families, both known to act in
endosomal trafficking.  The bMERB domain displays a preference for Rab8 family
proteins (Rab8,  10, 13 and 15) and at least some of the bMERB domains contain
two separate binding sites for Rab-proteins, allowing Micals and EHBPs to bind
two Rabs  simultaneously.  The strong similarity between the two binding sites
within one  bMRB  domain  strongly  suggests an evolutionarily development via
duplication of a common ancestor supersecondary structure element [1].

The bMERB  domain  has a completely alpha-helical fold consisting of a central
helix and  N-  and  C-terminal helices folding back on this central helix (see
<PDB:5SZJ>) [1].

Some proteins known to contain a bMERB domain are listed below:

 - Animal  proteins  of  the  Molecules  Interacting with CasL (Mical) family,
   multidomain, mainly cytoplasmic, proteins, which participate in the control
   of actin cytoskeleton dynamics.
 - Animal Eps15-homolgy (EH) domain binding proteins (EHBPs), couple vesicular
   transport to the actin cytoskeleton.
 - Animal C16orf45 proteins.

The profile we developed covers the entire bMERB domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: November 2017 / First entry.

[ 1] Rai A., Oprisko A., Campos J., Fu Y., Friese T., Itzen A., Goody R.S.,
     Gazdag E.M., Muller M.P.
     "bMERB domains are bivalent Rab8 family effectors evolved by gene
     duplication."
     Elife 5:0-0(2016).
     PubMed=27552051; DOI=10.7554/eLife.18675

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