{PDOC51849}
{PS51849; RSGI_N}
{BEGIN}
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* RsgI N-terminal anti-sigma domain profile *
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Bacterial response   to   transient   stresses  is  mediated  largely  through
transcription of relevant genes directed by sigma factors. Some of the stress-
responding sigma  genes  are  associated  with  anti-sigma factor genes, whose
products inhibit  the  activity of sigma factors through direct binding, which
is disrupted upon stress through phosphorylation by anti-anti-sigma factors or
digestion by  endogenous  proteases.  The Bacillus subtilis bicistronic operon
sigI-rsgI encodes  for  an  alternative  sigma(I) factor and its cognate anti-
sigma(I) regulator  RsgI that is functionally regulated by an extracytoplasmic
signal. Interaction of the ~50- to ~60-residue N-terminal intracellular domain
of the transmembrane protein RsgI with SigI sequesters and inactivates SigI on
the inner surface of the cytoplasmic membrane. Homologues of SigI and RsgI are
found in  many  species of the phylum Firmicutes. The extracellular modules of
these RsgI-like  proteins appear to have polysaccharide-related functions, and
include carbohydrate-binding  modules  (e.g.,  CBM3 (see <PDOC51172>), CBM42),
sugar-binding elements   (e.g.,  PA14  (see  <PDOC51820>)),  and  a  glycoside
hydrolase family 10 (GH10) (see <PDOC00510>) module [1,2,3,4].

The profile we developed covers the entire RsgI N-terminal anti-sigma domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: November 2017 / First entry.

[ 1] Asai K., Ootsuji T., Obata K., Matsumoto T., Fujita Y., Sadaie Y.
     "Regulatory role of RsgI in sigI expression in Bacillus subtilis."
     Microbiology 153:92-101(2007).
     PubMed=17185538; DOI=10.1099/mic.0.29239-0
[ 2] Kahel-Raifer H., Jindou S., Bahari L., Nataf Y., Shoham Y.,
     Bayer E.A., Borovok I., Lamed R.
     "The unique set of putative membrane-associated anti-sigma factors in
     Clostridium  thermocellum suggests a novel extracellular
     carbohydrate-sensing mechanism involved in gene regulation."
     FEMS Microbiol. Lett. 308:84-93(2010).
     PubMed=20487018; DOI=10.1111/j.1574-6968.2010.01997.x
[ 3] Nataf Y., Bahari L., Kahel-Raifer H., Borovok I., Lamed R.,
     Bayer E.A., Sonenshein A.L., Shoham Y.
     "Clostridium thermocellum cellulosomal genes are regulated by
     extracytoplasmic polysaccharides via alternative sigma factors."
     Proc. Natl. Acad. Sci. U.S.A. 107:18646-18651(2010).
     PubMed=20937888; DOI=10.1073/pnas.1012175107
[ 4] Liu T.-Y., Chu S.-H., Hu Y.-N., Wang J.-J., Shaw G.-C.
     "Genetic evidence that multiple proteases are involved in modulation
     of heat-induced activation of the sigma factor SigI in Bacillus
     subtilis."
     FEMS Microbiol. Lett. 364:0-0(2017).
     PubMed=28333276; DOI=10.1093/femsle/fnx054

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