{PDOC51854}
{PS51854; CSPG}
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* CSPG repeat profile *
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The CSPG  (chondroitin  sulfate  proteoglycan)  repeat  is a cadherin-like and
tumor-relevant protein module which is thought to mediate interactions between
cells and   the   extracellular  matrix  (ECM)  in  species  as  divergent  as
cyanobacteria, fly,  worm,  sea urchin and human. The phyletic distribution of
the CSPG  repeats  suggests that horizontal gene transfer contributed in their
evolutionary history.  The  CSPG  domain  occurs  in  1-15  tandem  copies per
protein. In  some  proteins the CSPG repeat is combined with Laminin G domains
(see <PDOC50025>) and EGF-like domains [1,2].

The CSPG  repeat  is  likely  to  obtain an all-beta fold, possibly comprising
eight beta-strands.  The  sixth  beta-strand  starts with a conserved aromatic
residue, which  is  followed  by  a  conserved  serine or threonine. Conserved
acidic residues  are  present in the subsequent loop regions between strands 6
and 7,  as  well  as  between 7 and 8. For most beta-strands one can observe a
typical  alternating pattern  of  hydrophobic  and  non-hydrophobic  residues.
Hydrophobic side  chains  that  point  to  the same side of the beta-sheet are
probably  buried in the interior of the CSPG domain [1].

Some proteins known to contain a CSPG repeat are listed below:

 - Mammalian  Fras1/Frem  family  of ECM proteins, associated with epithelial-
   mesenchymal cohesion during embryonic development.
 - Human melanoma-associated chondroitin sulfate proteoglycan (MCSP).
 - Rat NG2, the putative rat ortholog of MCSP.

The profile we developed covers the entire CSPG repeat.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: January 2018 / First entry.

[ 1] Staub E., Hinzmann B., Rosenthal A.
     "A novel repeat in the melanoma-associated chondroitin sulfate
     proteoglycan defines a new protein family."
     FEBS Lett. 527:114-118(2002).
     PubMed=12220645
[ 2] Pavlakis E., Chiotaki R., Chalepakis G.
     "The role of Fras1/Frem proteins in the structure and function of
     basement membrane."
     Int. J. Biochem. Cell Biol. 43:487-495(2011).
     PubMed=21182980; DOI=10.1016/j.biocel.2010.12.016

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