{PDOC51879}
{PS51879; RST}
{BEGIN}
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* RST domain profiles *
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The RST  (for  RCD1  SRO TAF4) domain is a plant-specific domain found in WWE-
PARPs (poly(ADP-ribose)  polymerase)  (see  <PDOC50918>  and  <PDOC51059>) and
TAF4s (TBP-Associated  Factor  4),  a  component of several multimeric protein
complexes including  primarily the general transcription factor TFIID involved
in transcriptional initiation. The RST domain is a protein-protein interaction
domain suggested  to  be  critical  for  the  interaction with several, mostly
plant-specific transcription factors [1,2].

The RST  domain  structure  has  a unique helical arrangement composed of four
alpha helices  flanked  by disordered termini (see <PDB:5OAO>). The four-helix
fold of the RST domain organizes in an open, hydrophobic L-shape with room for
catching the  ligand [3]. A strong conservation of a large number of aliphatic
amino acids  in  the  N-  and  C-termini  of  the RST domain, with a conserved
tyrosine in  the  middle  of  the  domain and two conserved positively charged
amino acids in the second half of the domain, is striking [1].

The profile we developed covers the entire RST domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: November 2018 / First entry.

[ 1] Jaspers P., Overmyer K., Wrzaczek M., Vainonen J.P., Blomster T.,
     Salojaervi J., Reddy R.A., Kangasjaervi J.
     "The RST and PARP-like domain containing SRO protein family: analysis
     of protein structure, function and conservation in land plants."
     BMC Genomics 11:170-170(2010).
     PubMed=20226034; DOI=10.1186/1471-2164-11-170
[ 2] Jaspers P., Blomster T., Brosche M., Salojaervi J., Ahlfors R.,
     Vainonen J.P., Reddy R.A., Immink R., Angenent G., Turck F.,
     Overmyer K., Kangasjaervi J.
     "Unequally redundant RCD1 and SRO1 mediate stress and developmental
     responses and  interact with transcription factors."
     Plant J. 60:268-279(2009).
     PubMed=19548978; DOI=10.1111/j.1365-313X.2009.03951.x
[ 3] Bugge K., Staby L., Kemplen K.R., O'Shea C., Bendsen S.K.,
     Jensen M.K., Olsen J.G., Skriver K., Kragelund B.B.
     "Structure of Radical-Induced Cell Death1 Hub Domain Reveals a Common
     alphaalpha-Scaffold for Disorder in Transcriptional Networks."
     Structure 26:734-746.e7(2018).
     PubMed=29657132; DOI=10.1016/j.str.2018.03.013

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