{PDOC51880}
{PS51880; TGS}
{BEGIN}
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* TGS domain profile *
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The TGS  domain,  named  after  the  presence in ThrRS, GTPase, and SpoT, is a
small domain  that  consists  of  ~50 amino acid residues and has nucleic acid
binding affinity.  It is shared by eukaryotic and some of the bacterial ThrRS,
a distinct  family  of  GTPases  (the OBG family), and guanosine polyphosphate
hydrolase (SpoT)  and  synthetase  (RelA),  which  are  involved  in stringent
response in  bacteria,  and  uridine  kinase  from  the  spirochaete Treponema
pallidum (but  not  any  other  organisnm,  including  the related spirochaete
Borrelia burgdorferi).  The  presence  of  the  TGS  domain  in  two  types of
regulatory proteins     (the     GTPases     and    guanosine    polyphosphate
phosphohydrolases/synthetases) suggests  a  ligand  (most  likely nucleotide)-
binding, regulatory role [1,2].

The TGS  domain  features  a  six-stranded  half-barrel  that curves around an
alpha-helix (see  <PDB:1JAL>)  and  belongs to the beta-grasp fold superfamily
[3,4,5].

The profile we developed covers the entire TGS domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2018 / First entry.

[ 1] Wolf Y.I., Aravind L., Grishin N.V., Koonin E.V.
     "Evolution of aminoacyl-tRNA synthetases--analysis of unique domain
     architectures  and phylogenetic trees reveals a complex history of
     horizontal gene transfer events."
     Genome Res. 9:689-710(1999).
     PubMed=10447505
[ 2] Cheung M.Y., Li X., Miao R., Fong Y.-H., Li K.-P., Yung Y.-L., Yu M.-H.,
     Wong K.-B., Chen Z., Lam H.-M.
     "ATP binding by the P-loop NTPase OsYchF1 (an unconventional G
     protein) contributes to biotic but not abiotic stress responses."
     Proc. Natl. Acad. Sci. U. S. A. 113:2648-2653(2016).
     PubMed=26912459; DOI=10.1073/pnas.1522966113
[ 3] Teplyakov A., Obmolova G., Chu S.Y., Toedt J., Eisenstein E.,
     Howard A.J., Gilliland G.L.
     "Crystal structure of the YchF protein reveals binding sites for GTP
     and nucleic acid."
     J. Bacteriol. 185:4031-4037(2003).
     PubMed=12837776
[ 4] Koller-Eichhorn R., Marquardt T., Gail R., Wittinghofer A.,
     Kostrewa D., Kutay U., Kambach C.
     "Human OLA1 defines an ATPase subfamily in the Obg family of
     GTP-binding proteins."
     J. Biol. Chem. 282:19928-19937(2007).
     PubMed=17430889; DOI=10.1074/jbc.M700541200
[ 5] Iyer L.M., Burroughs A.M., Aravind L.
     "The prokaryotic antecedents of the ubiquitin-signaling system and the
     early evolution of ubiquitin-like beta-grasp domains."
     Genome Biol. 7:R60-R60(2006).
     PubMed=16859499; DOI=10.1186/gb-2006-7-7-r60

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