{PDOC51881}
{PS51881; OCT}
{BEGIN}
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* Obg C-terminal (OCT) domain profile *
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Obg subfamily  proteins  (also  known as ObgE, YhbZ and CgtA) are conserved P-
loop GTPases,  that  are  involved  in  a  wide  range  of cellular processes,
including sporulation,   cellular   differentiation,  ribosome  assembly,  DNA
replication, chromosome  segregation, and stringent response in eubacteria and
plant chloroplasts.  Obg  subfamily proteins have three domains: the Obg fold,
the G  domain  (see  <PDOC51710>),  and  the  Obg  C-terminal  (OCT) domain. A
potential role  of  the OCT domain in the regulation of the nucleotide-binding
state has been suggested [1,2,3].

The OCT  domain  structure contains a four-stranded beta sheet and three alpha
helices flanked by an additional beta strand (see <PDB:1UDX>) [1].

The profile we developed covers the entire OCT domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2018 / First entry.

[ 1] Kukimoto-Niino M., Murayama K., Inoue M., Terada T., Tame J.R.H.,
     Kuramitsu S., Shirouzu M., Yokoyama S.
     "Crystal structure of the GTP-binding protein Obg from Thermus
     thermophilus HB8."
     J. Mol. Biol. 337:761-770(2004).
     PubMed=15019792; DOI=10.1016/j.jmb.2004.01.047
[ 2] Bang W.Y., Chen J., Jeong I.S., Kim S.W., Kim C.W., Jung H.S.,
     Lee K.H., Kweon H.-S., Yoko I., Shiina T., Bahk J.D.
     "Functional characterization of ObgC in ribosome biogenesis during
     chloroplast development."
     Plant. J. 71:122-134(2012).
     PubMed=22380942; DOI=10.1111/j.1365-313X.2012.04976.x
[ 3] Bang W.Y., Hata A., Jeong I.S., Umeda T., Masuda T., Chen J., Yoko I.,
     Suwastika I.N., Kim D.W., Im C.H., Lee B.H., Lee Y., Lee K.W.,
     Shiina T., Bahk J.D.
     "AtObgC, a plant ortholog of bacterial Obg, is a chloroplast-targeting
     GTPase essential for early embryogenesis."
     Plant Mol. Biol. 71:379-390(2009).
     PubMed=19636801; DOI=10.1007/s11103-009-9529-3

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{END}