{PDOC51890}
{PS51890; DAZ}
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* DAZ domain profile *
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DAZ (Deleted  in  Azoospermia)  proteins  are found almost exclusively in germ
cells in distant animal species. Deletion or mutations of their encoding genes
usually impair  either  oogenesis  or  spermatogenesis  or  both.  The  family
includes three  members,  Boule  (or  Boll), Dazl (or Dazla) and DAZ, encoding
RNA binding proteins. Boule is the ancestral gene that is conserved from flies
to humans, whereas, Dazl arose in the early vertebrate lineage and Daz arrived
on Y  chromosome during primate evolution. Basically, DAZ family proteins have
been proposed to function as adaptors for target mRNA transport and activators
of their  translation.  These proteins have a highly conserved RNA recognition
motif (RRM)  (see  <PDOC00030>)  for  binding  target mRNAs and one (Boule and
Dazl) or  multiple copies (Daz) of the DAZ domain, a 24 amino acids motif rich
in Asn,  Tyr,  and  Gln residues. The function of the DAZ domain is not known,
but may be involved in protein-protein interactions [1,2,3,4,5].

The profile we developed covers the entire DAZ domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: April 2019 / First entry.

[ 1] Fu X.-F., Cheng S.-F., Wang L.-Q., Yin S., De Felici M., Shen W.
     "DAZ Family Proteins, Key Players for Germ Cell Development."
     Int. J. Biol. Sci. 11:1226-1235(2015).
     PubMed=26327816; DOI=10.7150/ijbs.11536
[ 2] Xu E.Y., Moore F.L., Pera R.A.R.
     "A gene family required for human germ cell development evolved from
     an ancient meiotic gene conserved in metazoans."
     Proc. Natl. Acad. Sci. U. S. A. 98:7414-7419(2001).
     PubMed=11390979; DOI=10.1073/pnas.131090498
[ 3] Sekizaki H., Takahashi S., Tanegashima K., Onuma Y., Haramoto Y.,
     Asashima M.
     "Tracing of Xenopus tropicalis germ plasm and presumptive primordial
     germ cells with the Xenopus tropicalis DAZ-like gene."
     Dev. Dyn. 229:367-372(2004).
     PubMed=14745962; DOI=10.1002/dvdy.10448
[ 4] Xu H., Li Z., Li M., Wang L., Hong Y.
     "Boule is present in fish and bisexually expressed in adult and
     embryonic germ cells of medaka."
     PLoS One. 4:E6097-E6097(2009).
     PubMed=19564913; DOI=10.1371/journal.pone.0006097
[ 5] Rengaraj D., Zheng Y.H., Kang K.S., Park K.J., Lee B.R., Lee S.I.,
     Choi J.W., Han J.Y.
     "Conserved expression pattern of chicken DAZL in primordial germ cells
     and germ-line cells."
     Theriogenology 74:765-776(2010).
     PubMed=20537692; DOI=10.1016/j.theriogenology.2010.04.001

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