{PDOC51893} {PS51893; AKAP_CAM_BD} {BEGIN} ***************************************************************************************** * A kinase-anchoring proteins AKAP-5 and AKAP-12 calmodulin (CaM)-binding motif profile * ***************************************************************************************** The A kinase-anchoring proteins AKAP-5 and AKAP-12 (Gravin) bind calmodulin (CaM), a Ca(2+)-sensing protein that is expressed in all eukaryotic cells and mediates many essential processes driven by Ca(2+), including long-term changes in synaptic connections in the brain, apoptosis, and immune responses. The AKAP CaM-binding motif contains hydrophobic amino acids in a 1-4-7-8 pattern within an helix (see ) [1]. The profile we developed covers the entire AKAP CaM-binding motif. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: April 2019 / First entry. [ 1] Patel N., Stengel F., Aebersold R., Gold M.G. "Molecular basis of AKAP79 regulation by calmodulin." Nat. Commun. 8:1681-1681(2017). PubMed=29162807; DOI=10.1038/s41467-017-01715-w -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}