{PDOC51938} {PS51938; SUZ_C} {BEGIN} ************************ * SUZ-C domain profile * ************************ Microtubules are organized by the centrosome, a dynamic organelle that exhibits changes in both size and number during the cell cycle. The centrosome consists of a pair of centrioles surrounded by a mass of pericentriolar material (PCM). In Caenorhabditis elegans, SZY-20 is a centrosome-associated RNA-binding protein that negatively regulates centrosome assembly. SZY-20 and its animal orthologs share three prominent blocks of conservation. The N- terminal block is a short element, which is found exclusively in orthologs of SZY-20. The second block in the center of the protein, termed the SUZ domain (see ), is the strongest stretch of conservation and is enriched in charged residues. The third block, the SUZ-C domain, is at the extreme C- terminus and is defined by a characteristic pattern of two highly conserved glycines and one absolutely conserved proline. The SUZ and SUZ-C domains occur independently in proteins outside of the SZY-20 family. Many of these proteins contain known RNA-binding domains. The SUZ-C domain is a putative RNA-binding domain [1,2]. Some proteins known to contain a SUZ-C domain are listed below: - Caenorhabditis elegans SZY-20, - Animal orthologs of Caenorhabditis elegans SZY-20. - Animal Cold shock domain-containing protein E1 (CSDE1), an RNA-binding protein. - Vertebrate La-related protein 6 (LARP6) or Acheron (Achn), conserved member of the Lupus antigen family of RNA binding proteins. The profile we developed covers the entire SUZ-C domain. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: August 2020 / First entry. [ 1] Song M.H., Aravind L., Mueller-Reichert T., O'Connell K.F. "The conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size." Dev. Cell. 15:901-912(2008). PubMed=19081077; DOI=10.1016/j.devcel.2008.09.018 [ 2] Stubenvoll M.D., Medley J.C., Irwin M., Song M.H. "ATX-2, the C. elegans Ortholog of Human Ataxin-2, Regulates Centrosome Size and Microtubule Dynamics." PLoS Genet. 12:E1006370-E1006370(2016). PubMed=27689799; DOI=10.1371/journal.pgen.1006370 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}