{PDOC51978}
{PS51978; PBC}
{BEGIN}
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* PBC domain profile *
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The homeobox   transcription  factors  (TFs)  are  ubiquitous  in  eukaryotes,
carrying a  DNA-binding  homeodomain  typically 60 amino acids that folds into
three alpha-helices.   Homeodomain  proteins  are  classified  into  different
classes based  on  the  sequence  of the homeodomain itself, as well as on the
basis of additional conserved domains found in these proteins. The atypical or
TALE (three-amino  acid  length extension) superclass of homeobox TFs shares a
three-amino-acid insertion  between  helix  1  and 2 and plays essential roles
during embryonic  development by participating in interactive TF networks. The
heterodimerization of  TALE proteins serves as a trigger for precise execution
of developmental  programs.  TALE-heterodimerization  is  mediated  by  class-
specific homology  domains  located  on  the  N-terminal  side adjacent to the
homeodomain. The  PBC class of TALE homeodomain proteins includes the products
of the  vertebrate  Pbx1,  Pbx2, Pbx3 and Pbx4, Caenorhabditis elegans ceh-20,
ceh-40 and  ceh-60  and the Drosophila extradenticle (exd) genes. The sequence
similarity between  the PBC proteins extends downstream of the homeodomain for
about 15  amino  acids,  and  upstream  of the homeodomain is a 180-amino acid
domain termed  PBC.  The  PBC domain can be further subdivided into an A and B
region [1,2,3,4,5,6,7,8].

The profile we developed covers the entire PBC domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: June 2021 / First entry.

[ 1] Buerglin T.R., Ruvkun G.
     "New motif in PBX genes."
     Nat. Genet. 1:319-320(1992).
     PubMed=1363814; DOI=10.1038/ng0892-319
[ 2] Buerglin T.R.
     "Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX,
     Iroquois, TGIF) reveals a novel domain conserved between plants and
     animals."
     Nucleic. Acids. Res. 25:4173-4180(1997).
[ 3] Buerglin T.R.
     "The PBC domain contains a MEINOX domain: coevolution of Hox and TALE
     homeobox genes?"
     Dev. Genes. Evol. 208:113-116(1998).
     PubMed=9569353; DOI=10.1007/s004270050161
     PubMed=9336443; DOI=10.1093/nar/25.21.4173
[ 4] Berthelsen J., Kilstrup-Nielsen C., Blasi F., Mavilio F.,
     Zappavigna V.
     "The subcellular localization of PBX1 and EXD proteins depends on
     nuclear import and export signals and is modulated by association with
     PREP1 and HTH."
     Genes. Dev. 13:946-953(1999).
     PubMed=10215622; DOI=10.1101/gad.13.8.946
[ 5] Kilstrup-Nielsen C., Alessio M., Zappavigna V.
     "PBX1 nuclear export is regulated independently of PBX-MEINOX
     interaction by PKA phosphorylation of the PBC-B domain."
     EMBO. J. 22:89-99(2003).
     PubMed=12505987; DOI=10.1093/emboj/cdg010
[ 6] Mukherjee K., Buerglin T.R.
     "Comprehensive analysis of animal TALE homeobox genes: new conserved
     motifs and cases of accelerated evolution."
     J. Mol. Evol. 65:137-153(2007).
     PubMed=17665086; DOI=10.1007/s00239-006-0023-0
[ 7] Buerglin T.R., Affolter M.
     "Homeodomain proteins: an update."
     Chromosoma 125:497-521(2016).
     PubMed=26464018; DOI=10.1007/s00412-015-0543-8
[ 8] Joo S., Wang M.H., Lui G., Lee J., Barnas A., Kim E., Sudek S.,
     Worden A.Z., Lee J.-H.
     "Common ancestry of heterodimerizing TALE homeobox transcription
     factors across Metazoa and Archaeplastida."
     BMC Biol. 16:136-136(2018).
     PubMed=30396330; DOI=10.1186/s12915-018-0605-5

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