{PDOC51983}
{PS51983; CUTL}
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* CUT repeat-like (CUTL) domain profile *
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SATB (Special  AT-rich  binding  protein)  family proteins have emerged as key
regulators that   integrate   higher-order  chromatin  organization  with  the
regulation of  gene  expression. SATB family chromatin organizers are involved
in long-range  enhancer  function,  extension  of  chromatin modifications and
dynamic tethering  of chromatin loops, and play diverse and important roles in
regulating the  dynamic  equilibrium  of apoptosis, cell invasion, metastasis,
proliferation, angiogenesis,  and  immune  modulation.  SATB  family  proteins
consist of  an ubiquitin-like domain (ULD) (see <PDOC51982>) and a CUT repeat-
like (CUTL)  domain at the N terminus, a homeodomain (HD) (see <PDOC00027>) at
the C  terminus,  and  tandem CUT domains (see <PDOC51042>) in the center. The
DNA binding  ability of SATB1 requires the contribution of the CUTL domain, as
well as the tandem CUT domains and the homeodomain [1,2].

The profile we developed covers the entire CUTL domain.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: July 2021 / First entry.

[ 1] Naik R., Galande S.
     "SATB family chromatin organizers as master regulators of tumor
     progression."
     Oncogene 38:1989-2004(2019).
     PubMed=30413763; DOI=10.1038/s41388-018-0541-4
[ 2] Wang Z., Yang X., Guo S., Yang Y., Su X.-C., Shen Y., Long J.
     "Crystal structure of the ubiquitin-like domain-CUT repeat-like tandem
     of special  AT-rich sequence binding protein 1 (SATB1) reveals a
     coordinating DNA-binding mechanism."
     J. Biol. Chem. 289:27376-27385(2014).
     PubMed=25124042; DOI=10.1074/jbc.M114.562314

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