{PDOC52046}
{PS52046; ZF_C2HC_NPR}
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* Zinc finger C2HC NPR-type profile *
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Nonexpressor of  pathogenesis-related  genes 1 (NPR1) is a master regulator of
the defence  transcriptome  induced  by the plant immune signal salicylic acid
(SA). It  encodes  a  protein  with two protein-protein interaction domains, a
BTB/POZ domain  (see  <PDOC50097>)  at  the  N-terminus  and an ankyrin-repeat
domain (see  <PDOC50088>)  in  the  central  region. In response to SA-induced
redox changes,   NPR1  protein  is  released  from  a  quiescent  oligomer  to
translocate into the nucleus, where it serves as a coactivator in complex with
transcription factors  (TFs),  such  as TGAs, a family of basic leucine zipper
(bZIP) TGACG  motif-binding transcription factors. NPR1 is the founding member
of a  unique  family  of  proteins  divided  into  three functionally distinct
clades. Each  of  the three clades contains two family members with functional
redundancy. In  the  first  clade,  NPR1  and NPR2 are SA receptors and act as
transcriptional co-activators in plant immunity. In the second clade, NPR3 and
NPR4 are also SA receptors and serve as transcriptional co-repressors in plant
defense. In  the  third  clade,  NPR5/BOP2 and NPR6/BOP1 are involved in plant
growth and development [1,2,3].

A prominent  feature  of  NPR proteins is the presence of a conserved cysteine
cluster within  the  BTB  domain.  These  cysteine  residues  together  with a
conserved histidine  (C-X-D-X(2,3)-C-X-H-X(2)-C) form a zinc finger motif that
bridges the BTB domain with the ANKs (see <PDB:7TAD>) [2,3].

The profile we developed covers the entire C2HC NPR-type zinc finger.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: July 2024 / First entry.

[ 1] Liu X., Liu Z., Niu X., Xu Q., Yang L.
     "Genome-Wide Identification and Analysis of the NPR1-Like Gene Family
     in Bread  Wheat and Its Relatives."
     Int. J. Mol. Sci. 20:0-0(2019).
     PubMed=31783558; DOI=10.3390/ijms20235974
[ 2] Kumar S., Zavaliev R., Wu Q., Zhou Y., Cheng J., Dillard L.,
     Powers J., Withers J., Zhao J., Guan Z., Borgnia M.J., Bartesaghi A.,
     Dong X., Zhou P.
     "Structural basis of NPR1 in activating plant immunity."
     Nature 605:561-566(2022).
     PubMed=35545668; DOI=10.1038/s41586-022-04699-w
[ 3] Zhou P., Zavaliev R., Xiang Y., Dong X.
     "Seeing is believing: Understanding functions of NPR1 and its paralogs
     in plant  immunity through cellular and structural analyses."
     Curr. Opin. Plant. Biol. 73:102352-102352(2023).
     PubMed=36934653; DOI=10.1016/j.pbi.2023.102352

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