{PDOC52063}
{PS52063; D10C}
{BEGIN}
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* D10C domain profile *
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The D10C domain, which contains ten well-conserved cysteine residues, is about
130 amino  acid residues in length, and is present in mainly in two classes of
proteins: class   1   includes  liver-specific  zona  pellucida  (ZP)  domain-
containing protein  (LZP),  uromodulin (UMOD) and pancreatic secretory granule
membrane major  glycoprotein GP2; class 2 includes von Willebrand factor D and
EGF domain-containing  proteins. Most of these proteins are membrane proteins,
extracellular proteins or nuclear membrane proteins [1,2].

The globular  D10C  domain  fold includes two 3(10) helices, nine beta-strands
(betaA-betaI) and  five  intermolecular  disulfides  (C1-C8, C2-C9, C3-C6, C4-
C10, C5-C7) (see <PDB:7P6R>) [2].

The profile we developed covers the entire D10C repeat.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: May 2025 / First entry.

[ 1] Yang H., Wu C., Zhao S., Guo J.
     "Identification and characterization of D8C, a novel domain present in
      liver-specific LZP, uromodulin and glycoprotein 2, mutated in
     familial juvenile  hyperuricaemic nephropathy."
     FEBS. Lett. 578:236-238(2004).
     PubMed=15589826; DOI=10.1016/j.febslet.2004.10.092
[ 2] Stsiapanava A., Xu C., Nishio S., Han L., Yamakawa N., Carroni M.,
     Tunyasuvunakool K., Jumper J., de Sanctis D., Wu B., Jovine L.
     "Structure of the decoy module of human glycoprotein 2 and uromodulin
     and its  interaction with bacterial adhesin FimH."
     Nat. Struct. Mol. Biol. 29:190-193(2022).
     PubMed=35273390; DOI=10.1038/s41594-022-00729-3

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