{PDOC60031}
{PS60031; GARP2}
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* Glutamic acid-rich protein 2 (GARP2) signature *
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The glutamic  acid-rich  protein  2  (GARP2  is a soluble retinal protein that
exists in  rod  outer  segments  but is absent in cones. GARP2 is a product of
alternative splicing of the beta-subunit of the cGMP-gated ion channel (CNGB1)
of rod photoreceptors and contains a unique 8-amino-acid C-terminal extension.
It has  a high content of proline and glutamate residues. GARP2 has been shown
to bind to several retinal proteins including perpherin, and the photoreceptor
phosphodiesterase (PDE6) [1,2].

As a signature we used the five last common amino acid and the unique 8-amino-
acid C-terminal extension of GARP2.

-Consensus pattern: C-D-V-Q-T-R-[VAE]-[MVT]-[GA]-A-G-[GS]-L
                    [The 8  last  positions  correspond to the unique 8-amino-
                    acid C-terminal extension]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Expert(s) to contact by email:
           Cote R.; rick.cote@unh.edu

-Last update: March 2015 / First entry.

[ 1] Pentia D.C., Hosier S., Cote R.H.
     "The glutamic acid-rich protein-2 (GARP2) is a high affinity rod
     photoreceptor phosphodiesterase (PDE6)-binding protein that modulates
     its catalytic properties."
     J. Biol. Chem. 281:5500-5505(2006).
     PubMed=16407240; DOI=10.1074/jbc.M507488200
[ 2] Gibriel A.A.Y., Tate R.J., Yu Y., Rawson-Lax E., Hammer H.M.,
     Tettey J.N.A., Pyne N.J., Converse C.A.
     "The p.Arg86Gln change in GARP2 (glutamic acid-rich protein-2) is a
     common West African-related polymorphism."
     Gene 515:155-158(2013).
     PubMed=23201897; DOI=10.1016/j.gene.2012.11.005

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