ID   SUBTILASE_HIS; PATTERN.
AC   PS00137;
DT   01-APR-1990 CREATED; 01-NOV-1997 DATA UPDATE; 27-MAR-2024 INFO UPDATE.
DE   Serine proteases, subtilase family, histidine active site.
PA   H-G-[STM]-x-[VIC]-[STAGC]-[GS]-x-[LIVMA]-[STAGCLV]-[SAGM].
NR   /RELEASE=2024_02,571282;
NR   /TOTAL=247(247); /POSITIVE=232(232); /UNKNOWN=0(0); /FALSE_POS=15(15);
NR   /FALSE_NEG=8; /PARTIAL=7;
CC   /TAXO-RANGE=A?EP?; /MAX-REPEAT=1;
CC   /SITE=1,active_site;
CC   /VERSION=1;
DR   P09230    , AEP_YARLI  , T; P91863    , AEX5_CAEEL , T;
DR   B0Y473    , ALP2_ASPFC , T; P87184    , ALP2_ASPFU , T;
DR   P29118    , ALP_HAPCH  , T; Q03420    , ALP_HYPAT  , T;
DR   Q68GV9    , ALP_LECPS  , T; O31788    , APRX_BACSU , T;
DR   P08594    , AQL1_THEAQ , T; R4IR27    , ASES_SARSR , T;
DR   Q9L5A4    , ASP_AERSO  , T; P51559    , BLI4_CAEEL , T;
DR   A0A044RE18, BLI_ONCVO  , T; P42779    , BPRV_DICNO , T;
DR   P42780    , BPRX_DICNO , T; P58099    , C5AP_STRP1 , T;
DR   P0DD34    , C5AP_STRP3 , T; Q5X9R0    , C5AP_STRP6 , T;
DR   Q8NZ80    , C5AP_STRP8 , T; P0DD35    , C5AP_STRPQ , T;
DR   P15926    , C5AP_STRPY , T; B7ZK61    , CH901_DAVTA, T;
DR   B3V0K8    , CL401_COCLU, T; Q9LNU1    , CRSP_ARATH , T;
DR   P29138    , CUDP_METAN , T; P27693    , ELYA_ALKAL , T;
DR   P20724    , ELYA_BACYA , T; P41363    , ELYA_HALH5 , T;
DR   P41362    , ELYA_SHOCL , T; P30199    , EPIP_STAEP , T;
DR   P23314    , EXPR_XANCP , T; O17798    , FKPC1_CAEEL, T;
DR   Q93LQ6    , FLS_FERPE  , T; P26016    , FUR11_DROME, T;
DR   P30430    , FUR1C_DROME, T; P30432    , FUR2_DROME , T;
DR   P29119    , FURI1_XENLA, T; Q28193    , FURIN_BOVIN, T;
DR   P09958    , FURIN_HUMAN, T; P23188    , FURIN_MOUSE, T;
DR   P23377    , FURIN_RAT  , T; I3R794    , HLY_HALMT  , T;
DR   P29143    , HLY_NATA1  , T; P11018    , ISP1_BACSU , T;
DR   P40903    , ISP6_SCHPO , T; P29139    , ISP_PAEPO  , T;
DR   P29140    , ISP_SHOCL  , T; P09231    , KEX1A_KLULA, T;
DR   O13359    , KEX2_CANAW , T; P13134    , KEX2_YEAST , T;
DR   Q09175    , KRP1_SCHPO , T; Q9Z2A8    , MBTP1_CRIGR, T;
DR   Q14703    , MBTP1_HUMAN, T; Q9WTZ2    , MBTP1_MOUSE, T;
DR   Q9WTZ3    , MBTP1_RAT  , T; O05458    , MYCP2_MYCTU, T;
DR   O53695    , MYCP3_MYCTU, T; I6YC58    , MYCP4_MYCTU, T;
DR   O53945    , MYCP5_MYCTU, T; Q9GLR1    , NEC1_BOVIN , T;
DR   P29120    , NEC1_HUMAN , T; P63239    , NEC1_MOUSE , T;
DR   P63240    , NEC1_MUSCO , T; P28840    , NEC1_RAT   , T;
DR   Q9GLR0    , NEC2_BOVIN , T; G5ECN9    , NEC2_CAEEL , T;
DR   Q9VBC7    , NEC2_DROME , T; P16519    , NEC2_HUMAN , T;
DR   P21661    , NEC2_MOUSE , T; Q03333    , NEC2_PIG   , T;
DR   Q5REC2    , NEC2_PONAB , T; P28841    , NEC2_RAT   , T;
DR   P29146    , NECA_HYDVU , T; P29145    , NECB_HYDVU , T;
DR   Q5RLZ1    , NEP_NATMA  , T; Q07596    , NISP_LACLL , T;
DR   A1CIA7    , ORYZ_ASPCL , T; B0Y708    , ORYZ_ASPFC , T;
DR   P35211    , ORYZ_ASPFL , T; B8N106    , ORYZ_ASPFN , T;
DR   P28296    , ORYZ_ASPFU , T; P12547    , ORYZ_ASPOR , T;
DR   Q00208    , ORYZ_EMENI , T; A1CWF3    , ORYZ_NEOFI , T;
DR   P16271    , P1P_LACLC  , T; P15293    , P2P_LACLC  , T;
DR   Q02470    , P2P_LACPA  , T; P15292    , P3P_LACLS  , T;
DR   P9WEW6    , PCH18_PENCH, T; P9WEW5    , PCH18_PENRB, T;
DR   Q6UW60    , PCSK4_HUMAN, T; P29121    , PCSK4_MOUSE, T;
DR   Q78EH2    , PCSK4_RAT  , T; Q9NJ15    , PCSK5_BRACL, T;
DR   Q92824    , PCSK5_HUMAN, T; Q04592    , PCSK5_MOUSE, T;
DR   P41413    , PCSK5_RAT  , T; P29122    , PCSK6_HUMAN, T;
DR   Q63415    , PCSK6_RAT  , T; Q16549    , PCSK7_HUMAN, T;
DR   Q61139    , PCSK7_MOUSE, T; Q62849    , PCSK7_RAT  , T;
DR   Q9P8G3    , PEN18_PENRB, T; Q9Y755    , PENC2_PENCI, T;
DR   P33295    , PEPC_ASPNG , T; P72186    , PLS_PYRFU  , T;
DR   Q1DFT5    , POPC_MYXXD , T; Q59149    , PRCA_NOSS1 , T;
DR   P23916    , PRCA_TRIV2 , T; P16588    , PROA_VIBAL , T;
DR   P09232    , PRTB_YEAST , T; P06873    , PRTK_PARAQ , T;
DR   Q99405    , PRTM_SHOC1 , T; P23653    , PRTR_PARAQ , T;
DR   P09489    , PRTS_SERMA , T; P20015    , PRTT_PARAQ , T;
DR   P29805    , PRTT_SERMA , T; Q9UTS0    , PSP3_SCHPO , T;
DR   Q32ZM1    , RM201_RHOMI, T; P25381    , RRT12_YEAST, T;
DR   F4HYR6    , SBT24_ARATH, T; F4JJH4    , SBT31_ARATH, T;
DR   Q9MAP5    , SBT33_ARATH, T; F4HPF1    , SBT34_ARATH, T;
DR   Q9ZSB0    , SBT39_ARATH, T; Q9ZSB1    , SBT3A_ARATH, T;
DR   Q1PDX5    , SBT3B_ARATH, T; F4JJH5    , SBT3C_ARATH, T;
DR   Q8GWX9    , SBT3G_ARATH, T; F4IG09    , SBT41_ARATH, T;
DR   F4HSQ2    , SBT51_ARATH, T; Q0WUG6    , SBT61_ARATH, T;
DR   P80146    , SEPR_THESR , T; Q9Y778    , SMP1_MAGPO , T;
DR   G1X8P8    , SPAZ_ARTOA , T; G3FNQ9    , SPAZ_ORBOL , T;
DR   Q8SQJ3    , SPL1_ENCCU , T; P58371    , SPM1_PYRO7 , T;
DR   D4AQG0    , SUB10_ARTBC, T; D4DIS6    , SUB10_TRIVH, T;
DR   Q8I0V0    , SUB1_PLAF7 , T; O61142    , SUB1_PLAFA , T;
DR   W7K9M0    , SUB1_PLAFO , T; L8G6I7    , SUB1_PSED2 , T;
DR   C5P6D1    , SUB2A_COCP7, T; C5NZ70    , SUB2C_COCP7, T;
DR   D4AZ75    , SUB2_ARTBC , T; Q64K35    , SUB2_ARTBE , T;
DR   E4UZP9    , SUB2_ARTGP , T; C5G168    , SUB2_ARTOC , T;
DR   Q8J0D8    , SUB2_ARTOT , T; Q9RYM8    , SUB2_DEIRA , T;
DR   Q8IHZ5    , SUB2_PLAF7 , T; O97364    , SUB2_PLAFA , T;
DR   Q9Y008    , SUB2_PLAFP , T; L8FSM5    , SUB2_PSED2 , T;
DR   B6VA85    , SUB2_TRIEQ , T; Q69F57    , SUB2_TRIRU , T;
DR   B8XGQ5    , SUB2_TRITO , T; Q5VJ76    , SUB2_TRIVC , T;
DR   D4DLI5    , SUB2_TRIVH , T; Q8I430    , SUB3_PLAF7 , T;
DR   L8GD75    , SUB3_PSED2 , T; C5NZT2    , SUB4B_COCP7, T;
DR   D4B194    , SUB5_ARTBC , T; Q64K32    , SUB5_ARTBE , T;
DR   E4V2L6    , SUB5_ARTGP , T; C5G1D1    , SUB5_ARTOC , T;
DR   B6VA87    , SUB5_TRIEQ , T; Q69F34    , SUB5_TRIRU , T;
DR   B8XGQ8    , SUB5_TRITO , T; Q5VJ73    , SUB5_TRIVC , T;
DR   D4D0F5    , SUB5_TRIVH , T; D4ALV9    , SUB6_ARTBC , T;
DR   Q64K31    , SUB6_ARTBE , T; E4V4J8    , SUB6_ARTGP , T;
DR   C5FQI3    , SUB6_ARTOC , T; A1XIH0    , SUB6_TRIEQ , T;
DR   Q9UW97    , SUB6_TRIRU , T; A1XIH1    , SUB6_TRISD , T;
DR   Q8J077    , SUB6_TRISH , T; Q3ZEJ8    , SUB6_TRITO , T;
DR   Q5VJ72    , SUB6_TRIVC , T; D4D5H3    , SUB6_TRIVH , T;
DR   C5PCX1    , SUB7B_COCP7, T; C5NZ69    , SUB7C_COCP7, T;
DR   D4APA9    , SUB7_ARTBC , T; Q64K36    , SUB7_ARTBE , T;
DR   E4V2V9    , SUB7_ARTGP , T; C5FJA5    , SUB7_ARTOC , T;
DR   A1XIH3    , SUB7_TRIEQ , T; Q8NID9    , SUB7_TRIRU , T;
DR   A1XIH5    , SUB7_TRISD , T; A1XIH4    , SUB7_TRITO , T;
DR   Q5VJ71    , SUB7_TRIVC , T; D4CZQ4    , SUB7_TRIVH , T;
DR   A1XIH6    , SUB7_TRIVO , T; D4AX50    , SUB8_ARTBC , T;
DR   C5FII2    , SUB8_ARTOC , T; C5P4Z8    , SUB8_COCP7 , T;
DR   D4DKQ4    , SUB8_TRIVH , T; P29599    , SUBB_LEDLE , T;
DR   P00780    , SUBC_BACLI , T; P00781    , SUBD_BACLI , T;
DR   P16396    , SUBE_BACSU , T; P16397    , SUBF_BACSU , T;
DR   P35835    , SUBN_BACNA , T; P29600    , SUBS_LEDLE , T;
DR   P00782    , SUBT_BACAM , T; P07518    , SUBT_BACPU , T;
DR   P28842    , SUBT_BACS9 , T; P00783    , SUBT_BACSA , T;
DR   P04189    , SUBT_BACSU , T; P29142    , SUBT_GEOSE , T;
DR   P29141    , SUBV_BACSU , T; P54683    , TAGB_DICDI , T;
DR   Q23868    , TAGC_DICDI , T; Q8T9W1    , TAGD_DICDI , T;
DR   Q45670    , THES_BACSJ , T; P04072    , THET_THEVU , T;
DR   Q5JIZ5    , TKSP_THEKO , T; A5PK39    , TPP2_BOVIN , T;
DR   Q09541    , TPP2_CAEEL , T; Q9V6K1    , TPP2_DROME , T;
DR   P29144    , TPP2_HUMAN , T; Q64514    , TPP2_MOUSE , T;
DR   Q64560    , TPP2_RAT   , T; Q9UT05    , TPP2_SCHPO , T;
DR   F4JVN6    , TPPII_ARATH, T; P54423    , WPRA_BACSU , T;
DR   P42781    , XPR6_YARLI , T; P25036    , YSP3_YEAST , T;
DR   P85157    , ASE2_ACRSP , P; P80406    , CUDP_METCM , P;
DR   P83454    , NCP3_COPCM , P; P83433    , NVSP_ALIVI , P;
DR   P28308    , PRTE_HALME , P; Q10721    , SP01_SCEBO , P;
DR   P13858    , THEM_MALCI , P;
DR   Q9JXM7    , NALP_NEIMB , N; E6MVD9    , NALP_NEIMH , N;
DR   A9QY40    , SBT1_LOTJA , N; A9QY39    , SBT3_LOTJA , N;
DR   A9QY38    , SBT4_LOTJA , N; A9JQS7    , SBTS_LOTJA , N;
DR   G7KEU7    , SBT_MEDTR  , N; A0A0M3R8G2, SBT_PETHY  , N;
DR   P40145    , ADCY8_HUMAN, F; P97490    , ADCY8_MOUSE, F;
DR   P40146    , ADCY8_RAT  , F; O27170    , DGGGP_METTH, F;
DR   Q6NVM2    , KTNB1_XENTR, F; Q7NH81    , PSBA3_GLOVI, F;
DR   Q9TM69    , PSBA_ALETA , F; Q9BBC1    , PSBA_AMPCA , F;
DR   Q7HP56    , PSBA_AMPOP , F; Q9MSC0    , PSBA_HETNI , F;
DR   Q9MSC1    , PSBA_HETPY , F; Q9MSC2    , PSBA_HETRO , F;
DR   Q9XQV1    , PSBA_HETTR , F; Q9TM72    , PSBA_PROMC , F;
DR   Q3UME2    , TM241_MOUSE, F;
3D   1A2Q; 1AF4; 1AH2; 1AK9; 1AQN; 1AU9; 1AV7; 1AVT; 1BE6; 1BE8; 1BFK; 1BFU;
3D   1BH6; 1BJR; 1C3L; 1C9J; 1C9M; 1C9N; 1CNM; 1CSE; 1DBI; 1DUI; 1EGQ; 1GCI;
3D   1GNS; 1GNV; 1HT3; 1IAV; 1IC6; 1JEA; 1LW6; 1MEE; 1MPT; 1NDQ; 1NDU; 1OT5;
3D   1OYO; 1OYV; 1P7V; 1P7W; 1P8J; 1PEK; 1PFG; 1PJ8; 1PTK; 1Q5P; 1R0R; 1R64;
3D   1S01; 1S02; 1SBC; 1SBH; 1SBI; 1SBN; 1SBT; 1SCA; 1SCB; 1SCD; 1SCJ; 1SCN;
3D   1SEL; 1SIB; 1SPB; 1ST2; 1ST3; 1SUA; 1SUB; 1SUC; 1SUD; 1SUE; 1SUP; 1SVN;
3D   1TEC; 1THM; 1TK2; 1TM1; 1TM3; 1TM4; 1TM5; 1TM7; 1TMG; 1TO1; 1TO2; 1UBN;
3D   1V5I; 1VSB; 1WSD; 1XF1; 1Y1K; 1Y33; 1Y34; 1Y3B; 1Y3C; 1Y3D; 1Y3F; 1Y48;
3D   1Y4A; 1Y4D; 1YJA; 1YJB; 1YJC; 1YU6; 2DP4; 2DQK; 2DUJ; 2G4V; 2HD4; 2HPZ;
3D   2ID4; 2ID8; 2PKC; 2PQ2; 2PRK; 2PWA; 2PWB; 2PYZ; 2SBT; 2SEC; 2SIC; 2SNI;
3D   2ST1; 2TEC; 2V8B; 2WUV; 2WUW; 3AFG; 3AJ8; 3AJ9; 3BGO; 3BX1; 3CNQ; 3CO0;
3D   3D9Q; 3DDZ; 3DE0; 3DE1; 3DE2; 3DE3; 3DE4; 3DE5; 3DE6; 3DE7; 3DVQ; 3DVR;
3D   3DVS; 3DW1; 3DW3; 3DWE; 3DYB; 3EIF; 3F49; 3F7M; 3GT3; 3GT4; 3HJR; 3I2Y;
3D   3I30; 3I34; 3I37; 3L1K; 3LXU; 3OSZ; 3PRK; 3PTL; 3Q40; 3Q5G; 3QMP; 3SIC;
3D   3TEC; 3UNX; 3VSB; 3VYV; 3WHI; 3WQB; 4B5L; 4C3U; 4C3V; 4CFY; 4CFZ; 4CG0;
3D   4DJ5; 4DWW; 4DZT; 4FON; 4LVN; 4LVO; 4MZD; 4OMC; 4OMD; 4RYD; 4WOB; 4WOC;
3D   4Z2A; 4ZAR; 5AMX; 5AQE; 5ARB; 5ARC; 5ARD; 5AVJ; 5AVK; 5B1D; 5B1E; 5CW1;
3D   5GL8; 5I9S; 5JMO; 5JXG; 5JXH; 5JXI; 5JXJ; 5K7S; 5KXU; 5KXV; 5MIM; 5MJL;
3D   5OX2; 5ROC; 5ROD; 5ROE; 5ROF; 5ROG; 5ROH; 5ROI; 5ROJ; 5ROK; 5ROL; 5ROM;
3D   5RON; 5ROO; 5ROP; 5ROQ; 5ROR; 5ROS; 5ROT; 5ROU; 5ROV; 5ROW; 5ROX; 5ROY;
3D   5ROZ; 5RP0; 5RP1; 5RP2; 5RP3; 5RP4; 5RP5; 5RP6; 5RP7; 5RP8; 5RP9; 5RPA;
3D   5RPB; 5RPC; 5RPD; 5RPE; 5RPF; 5RPG; 5RPH; 5RPI; 5RPJ; 5RPK; 5RPL; 5RPM;
3D   5RPN; 5RPO; 5RPP; 5RPQ; 5RPR; 5RPS; 5RPT; 5RPU; 5RPV; 5RPW; 5RPX; 5RPY;
3D   5RPZ; 5SIC; 5UVL; 5WHW; 5WJG; 5WJH; 5WRC; 6CL7; 6CL8; 6CL9; 6CLA; 6CLB;
3D   6DWQ; 6EQV; 6EQW; 6EQX; 6FJS; 6HLB; 6HLD; 6HLE; 6HZA; 6HZB; 6HZC; 6HZD;
3D   6J43; 6K2P; 6K2R; 6K2S; 6K2T; 6K2V; 6K2W; 6K2X; 6K8M; 6KKF; 6LAW; 6MH6;
3D   6N4U; 6O44; 6PAK; 6PKJ; 6PKK; 6PKL; 6PKM; 6PKN; 6PKO; 6PKP; 6PKQ; 6PKR;
3D   6PKS; 6PKT; 6PQ0; 6PQ4; 6PU4; 6PU5; 6QF1; 6QXV; 6RUG; 6RUH; 6RUK; 6RUN;
3D   6RUW; 6RVE; 6RVG; 6RZP; 6TXG; 6V8R; 6Y5S; 6Y5T; 6YD2; 6YD3; 6YD4; 6YD7;
3D   6ZET; 6ZEU; 6ZEV; 7A68; 7A9F; 7A9K; 7A9M; 7AM3; 7AM4; 7AM5; 7AM6; 7AM7;
3D   7AM8; 7BJ3; 7C0P; 7JSY; 7LCU; 7LN7; 7LPT; 7LPU; 7LPV; 7LQ8; 7LQ9; 7LQA;
3D   7LQB; 7LQC; 7LTD; 7LTI; 7LTV; 7LU0; 7LU1; 7LU2; 7LU3; 7NJJ; 7NP7; 7NPR;
3D   7NPS; 7NUY; 7NUZ; 7O1U; 7O1W; 7O1Y; 7O20; 7O22; 7QXY; 7QXZ; 7QY0; 7QY1;
3D   7QY2; 7S4Z; 7SKX; 7SVY; 7SVZ; 7SW0; 7SW1; 7SW2; 7SW3; 7SW4; 7SW5; 7SW6;
3D   7SW7; 7SW8; 7SW9; 7SWA; 7SWB; 7SWC; 7YZX; 8B4V; 8B4W; 8B4X; 8E52; 8E53;
3D   8E7F; 8F05; 8F06; 8F07; 8FYO; 8FYP; 8FYQ; 8FYR; 8FYS; 8SDK; 8SOG; 8SOU;
3D   8SOV; 8SPL; 8SQV;
PR   PRU10081;
DO   PDOC00125;
//