ID   LISH; MATRIX.
AC   PS50896;
DT   01-FEB-2003 CREATED; 13-FEB-2019 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
DE   LIS1 homology (LisH) motif profile.
MA   /GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=33;
MA   /DISJOINT: DEFINITION=PROTECT; N1=1; N2=33;
MA   /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=5.5517526; R2=0.0001392; TEXT='NScore';
MA   /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=124905.5937500; R2=0.2366895; PRIORITY=1; TEXT='Heuristic 5.0%';
MA   /CUT_OFF: LEVEL=0; SCORE=13997; H_SCORE=128219; N_SCORE=7.5; MODE=1; TEXT='!';
MA   /CUT_OFF: LEVEL=-1; SCORE=6813; H_SCORE=126518; N_SCORE=6.5; MODE=1; TEXT='?';
MA   /DEFAULT: B0=*; B1=*; E0=*; E1=*; MM=*; II=*;
MA   /I: B1=-8455; BM=-16; BD=-6459;
MA   /M: SY='Q'; M=-485,-655,565,524,-489,-2325,566,-2057,522,-37,-108,260,-475,1123,1061,491,-371,-1660,529,-1524; M0=-292;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='R'; M=-1258,-578,-168,465,-5430,-719,-25,-1026,1337,-1963,-4198,524,142,1208,1853,307,-650,-1554,-499,-4610; M0=-713;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='R'; M=-172,-5109,-592,941,-1863,-2339,269,-2490,1040,-1368,-1033,1139,-1014,984,1264,1045,-913,-777,-5292,-4610; M0=-670;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='E'; M=-373,-5102,1663,1945,-1859,-2532,-3271,-410,-260,380,592,-382,-2538,259,-73,-876,-42,-2726,-5287,-1467; M0=-708;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='L'; M=-1571,-3751,-6271,-5635,-24,-2868,-4345,1162,-5230,2373,1221,-1936,-5523,-4853,-5030,-881,-713,1311,-4210,-3868; M0=-2170;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='N'; M=-722,1180,1035,-1927,-1903,-4870,803,1166,-1881,298,-3608,2710,-1832,30,-3776,-1733,-1438,-634,-4793,280; M0=-1058;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='R'; M=-471,106,-3543,-398,325,-948,-891,-2248,796,-608,-1226,-639,-234,1153,2259,-94,-839,-596,-5217,378; M0=-510;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='L'; M=448,-770,-6268,-5632,-345,-5470,-953,1389,-5227,2323,1458,-5116,-5520,-925,-5027,-1400,-3863,-2014,-4206,1414; M0=-2319;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='I'; M=-6016,183,-8682,-8336,-2061,-8542,-8358,2997,-8294,-255,1125,-8201,-8156,-8001,-8349,-7928,-5992,2551,-7421,-7144; M0=-5211;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='Y'; M=671,-585,-5996,-1969,-384,-2615,991,-337,-200,1392,1503,-1025,-5481,-2455,-1273,-221,-1236,366,771,1836; M0=-916;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='Q'; M=-2088,-5109,1816,1651,-5431,-736,1240,-5181,-702,-2750,-4198,1446,-4703,1913,574,-336,-1161,-4731,-243,-4610; M0=-1592;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='Y'; M=-2838,-702,-8617,-8976,2713,-8493,3063,-7131,-8530,-3567,-6532,-7106,-8350,-7248,-7891,-7742,-8088,-7286,-3927,4009; M0=-5908;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='L'; M=-7253,1004,-9409,-8929,1469,-9210,-7001,-4195,-8698,3082,877,-8684,-4220,-7378,-8117,-8566,-7077,-5073,-5823,-1468; M0=-5564;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='Q'; M=-2596,-650,260,-104,-562,-1632,-944,109,191,932,-218,-67,-4762,1595,274,-1367,-1182,914,-5150,954; M0=-556;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='H'; M=-1270,-5108,-682,1358,-316,-4610,1984,-1500,1000,-2910,-4197,-91,-4703,980,1640,371,-184,-1196,1693,-4609; M0=-1114;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='N'; M=-261,1671,-3562,945,-878,-4651,1126,-1087,654,-2056,849,2088,-4742,1418,-886,228,-1132,-1753,-5195,315; M0=-991;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='G'; M=-2058,-536,-625,-1742,-5461,3145,-3295,-5212,488,-5156,-4230,1268,-4728,-352,-1936,-686,-3605,-4762,-5323,-1197; M0=-2202;
MA   /I: MM=-18; MI=-11609; MD=-6391; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='Y'; M=-628,-4528,-1233,-6359,1720,-6209,-965,-4034,-2061,1572,1297,-5707,-6237,-5497,-5731,-5308,-4684,-3978,-4079,3706; M0=-3072;
MA   /I: MM=-1; MI=-11592; MD=-12634; IM=-894; II=-1115; DM=-371; DD=-2142;
MA   /M: SY='H'; M=-2459,714,267,1029,-536,-1779,1692,-1430,1238,-659,-450,-491,-1860,249,-705,494,88,-78,-238,629; M0=-368;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='E'; M=-541,-5109,1462,1989,-1852,-2390,1614,-1574,521,-1251,-4198,831,-4703,562,150,-192,-1718,-2392,-5292,-491; M0=-917;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='T'; M=1253,-437,-6789,-6279,-4442,-5538,-5023,-2290,-5880,-1750,-3675,-5548,-2100,-5488,-5665,1340,2960,837,-4948,-4617; M0=-2829;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='A'; M=2725,-659,-5870,-219,730,-915,-1317,-1817,-1375,598,340,-4923,-5462,-1923,-1817,-1499,-3845,-565,-4248,-1444; M0=-1444;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='H'; M=647,-5107,-144,1454,-257,-2533,1866,-1010,1258,-1265,-1095,-1708,-4704,1506,233,-179,-888,-2286,-5291,-1048; M0=-772;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='T'; M=1363,1066,-4775,357,-4051,-2419,-3919,-2506,1014,-690,1163,-4253,-5216,-3879,-810,-518,1972,857,-4463,-4056; M0=-1350;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='F'; M=-7028,-6438,-9182,-8696,3452,-8885,-729,-2128,-8431,2324,162,-8356,-8126,-7245,-7913,-8176,-6870,-2184,-5689,-788; M0=-5266;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='Q'; M=524,1799,-2109,895,-1794,-1135,-3295,-201,134,328,46,-827,-2118,1835,670,-131,-1268,-720,-5236,-1528; M0=-459;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='K'; M=-469,-5109,-1116,1285,-1934,-4610,-434,-2156,1948,-567,-410,-2021,22,1433,1365,209,-1645,-4731,-5292,-1858; M0=-1051;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='E'; M=-528,-5361,-113,3511,-5676,-4766,-3480,-5434,-637,-5375,-1466,-1569,-4897,-124,-3614,-944,-1180,-4981,-5543,-4846; M0=-2626;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='T'; M=1436,1489,-6257,-5621,-3704,-1050,-4339,-1277,-5219,-631,-805,-467,-5518,-4844,-5023,1788,2193,-454,-4208,-1085; M0=-1944;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='G'; M=-1323,-768,309,-94,-5430,2115,667,-2841,1144,-2157,-4198,703,-1156,919,101,12,-563,-4731,-5292,-4610; M0=-1096;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='I'; M=-1546,230,-64,-342,236,-2964,-51,1395,-1899,1212,-922,-2055,-1045,246,-614,-630,-209,1265,-142,-4210; M0=-551;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='S'; M=-853,-5099,270,687,-963,-2036,-531,-438,405,-369,-392,-131,707,665,-1919,903,877,283,-5285,-1576; M0=-354;
MA   /I: MM=-1; MI=-11609; MD=-12651; IM=-894; II=-1115; DM=-701; DD=-1378;
MA   /M: SY='D'; M=-2169,-1710,889,280,-962,-344,-1035,-1011,645,628,-691,464,49,426,86,-241,-225,553,-5279,-1535; M0=-256;
MA   /I: E1=-1000;
CC   /MATRIX_TYPE=protein_domain;
CC   /SCALING_DB=reversed;
CC   /AUTHOR=CJA_Sigrist;
CC   /FT_KEY=DOMAIN; /FT_DESC=LisH;
CC   /VERSION=6;
PR   PRU00126;
DO   PDOC50896;
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