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PROSITE documentation PDOC51237 [for PROSITE entry PS51288]
ABC transporter family profiles


Description

ABC transporters belong to the ATP-Binding Cassette (ABC) superfamily which use the hydrolysis of ATP to energize diverse biological systems. It forms one of the largest of all protein families with a diversity of physiological functions (see <PDOC00185>) [1,2]. Several studies have shown that there is a correlation between the functional characterisation and the phylogenetic classification of the ABC cassette [2,4]. More than 50 families have been described based on a phylogenetic and functional classification [2,3,4] [E1].

Some ABC transporter families on which we developed a profile are listed below.

Active import transport system components:

  • Sulfate/thiosulfate import ATP-binding protein cysA (EC 3.6.3.25).
  • Phosphate import ATP-binding protein pstB (EC 3.6.3.27).
  • Molybdenum import ATP-binding protein modC (EC 3.6.3.29).
  • Ferric cations import ATP-binding protein fbpC (EC 3.6.3.30).
  • Maltose/maltodextrin import ATP-binding protein malK (EC 3.6.3.19).
  • Cobalt import ATP-binding protein cbiO.
  • Nickel import ATP-binding protein nikD/nikE (EC 3.6.3.24).
  • Phosphonates import ATP-binding protein phnC (EC 3.6.3.28).
  • Taurine import ATP-binding protein tauB (EC 3.6.3.36).
  • Ribose import ATP-binding protein rbsA (EC 3.6.3.17).
  • Galactose/methyl galactoside import ATP-binding protein mglA (EC 3.6.3.17).
  • Hemin import ATP-binding protein hmuV.
  • Methionine import ATP-binding protein metN.
  • Arabinose import ATP-binding protein araG (EC 3.6.3.17).
  • Xylose import ATP-binding protein xylG (EC 3.6.3.17).
  • Thiamine import ATP-binding protein thiQ.
  • Aliphatic sulfonate import ATP-binding protein ssuB.
  • Zinc import ATP-binding protein znuC.
  • Spermidine/putrescine import ATP-binding protein potA (EC 3.6.3.31).
  • sn-glycerol-3-phosphate import ATP-binding protein ugpC (EC 3.6.3.20).

Active export transport system components:

  • Lipid A export ATP-binding/permease protein msbA.
  • Nod factor export ATP-binding protein I.
  • Cytochrome c biogenesis ATP-binding export protein ccmA (EC 3.6.3.41).
  • Lipoprotein releasing system ATP-binding protein lolD.
  • Teichoic acids export ATP-binding protein tagH (EC 3.6.3.40).
  • Macrolide export ATP-binding/permease protein macB.
  • β-(1-->2)glucan export ATP-binding/permease protein ndvA (EC 3.6.3.42).

Each family profile was built on a discriminating region either in the ABC cassette or in the C-terminal region.

Last update:

June 2009 / Text revised.

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Technical section

PROSITE methods (with tools and information) covered by this documentation:

THIQ, PS51288; Thiamine import ATP-binding protein thiQ family profile  (MATRIX)

ARAG, PS51268; Arabinose import ATP-binding protein araG family profile  (MATRIX)

CBIO, PS51246; Cobalt import ATP-binding protein cbiO  (MATRIX)

CCMA, PS51243; Cytochrome C biogenesis export ATP-binding protein ccmA family profile  (MATRIX)

CYSA, PS51237; Sulfate/thiosulfate import ATP-binding protein cysA family profile  (MATRIX)

FBPC, PS51242; Ferric cations import ATP-binding protein fbpC family profile  (MATRIX)

HMUV, PS51261; Hemin import ATP-Binding protein hmuV family profile  (MATRIX)

LOLD, PS51244; Lipoprotein release ATP-binding protein lolD family profile  (MATRIX)

MACB, PS51267; Macrolide export ATP-binding/permease protein macB family profile  (MATRIX)

MALK, PS51245; Maltose/Maltodextrin import ATP-binding protein malK family profile  (MATRIX)

METN, PS51264; Methionine import ATP-binding protein metN family profile  (MATRIX)

MGLA, PS51260; Galactose/methyl galactoside import ATP-binding protein mglA family profile  (MATRIX)

MODC, PS51241; Molybdenum import ATP-binding protein modC family profile  (MATRIX)

MSBA, PS51239; Lipid A export ATP-binding/permease protein msbA family profile  (MATRIX)

NDVA, PS51317; Beta-(1-->2)glucan export ATP-binding/permease protein ndvA family profile  (MATRIX)

NIKD, PS51247; Nickel import ATP-binding protein nikD  (MATRIX)

NIKE, PS51248; Nickel import ATP-binding protein nikE  (MATRIX)

NODI, PS51240; Nod factors export ATP-binding protein I nodI family profile  (MATRIX)

PHNC, PS51249; Phosphonate import ATP-binding protein phnC  (MATRIX)

POTA, PS51305; Spermidine/putrescine import ATP-binding protein potA family profile  (MATRIX)

PSTB, PS51238; Phosphate import ATP-binding protein pstB family profile  (MATRIX)

RBSA, PS51254; Ribose import ATP-binding protein rbsA family profile  (MATRIX)

SSUB, PS51291; Aliphatic sulfonate import ATP-binding protein ssuB family profile  (MATRIX)

TAGH, PS51251; Teichoic acids export ATP-binding protein tagH  (MATRIX)

TAUB, PS51250; Taurine import ATP-binding protein tauB  (MATRIX)

UGPC, PS51315; sn-glycerol-3-phosphate import ATP-binding protein ugpC family profile  (MATRIX)

XYLG, PS51280; Xylose import ATP-binding protein xylG family profile  (MATRIX)

ZNUC, PS51298; Zinc import ATP-binding protein znuC family profile  (MATRIX)


References

1AuthorsHolland I.B. Cole S.P.C. Kuchler K. Higgins C.F.
Source(In) ABC proteins from bacteria to man, Academic Press, San Diego, (2003).

2AuthorsSaurin W. Hofnung M. Dassa E.
TitleGetting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters.
SourceJ. Mol. Evol. 48:22-41(1999).
PubMed ID9873074

3AuthorsHiggins C.F.
TitleABC transporters: physiology, structure and mechanism -- an overview.
SourceRes. Microbiol. 152:205-210(2001).
PubMed ID11421269

4AuthorsDassa E. Bouige P.
TitleThe ABC of ABCS: a phylogenetic and functional classification of ABC systems in living organisms.
SourceRes. Microbiol. 152:211-229(2001).
PubMed ID11421270

E1Sourcehttp://www.tcdb.org/tcdb/index.php?tc=3.A.1



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