AC   PRU00098;
DC   Domain;
TR   PROSITE; PS50221; GAIN_B; 1; level=0
XX
Names: GAIN-B domain
Function: The ~320-residue GAIN domain is an ancient domain that exists in
 primitive ancestor organisms, and is conserved in all adhesion-G-protein-
 coupled receptors (aGPCRs), all polycystic  kidney  disease 1 (PKD1)-like
 proteins and in other membrane-associated proteins like the sea urchin
 receptor for egg jelly protein (REJ). Functionally, the GAIN domain is both
 necessary and sufficient for autoproteolysis, suggesting an autoproteolytic
 mechanism whereby the overall GAIN domain fine-tunes the chemical
 environment.
XX
case <Feature:PS50221:145-147=H-[LM]-[TSC]>
CC   -!- SUBUNIT: Heterodimer of 2 chains generated by proteolytic processing;
CC       the large extracellular N-terminal fragment and the membrane-bound C-
CC       terminal fragment predominantly remain associated and non-covalently
CC       linked.
CC   -!- PTM: Autoproteolytically processed at the GPS region of the GAIN-B
CC       domain; this cleavage modulates receptor activity.
end case
XX
GO   GO:0016020; C:membrane
XX
KW   Glycoprotein
KW   Membrane
KW   Transmembrane
case <FTTag:disulf>
KW   Disulfide bond
end case
XX
FT   From: PS50221
FT   DOMAIN          from..to
FT                   /note="GAIN-B #"
FT   REGION          112..to
FT                   /note="GPS #"
FT   REGION          147..to
FT                   /note="Stachel #"
case <Feature:PS50221:145-147=H-[LM]-[TSC]>
FT   SITE            146..147
FT                   /note="Cleavage; by autolysis"
end case
FT   DISULFID        112..141
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        129..143
FT   Tag: disulf; Condition: C-x*-C
XX
Chop: Nter=0; Cter=0;
Size: 47-59;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: Q8IZF7;
Scope:
 Eukaryota; Metazoa
Comments: None
XX
# Version: 12
# Last updated date: 2024-02-23
# Created date: 2003-12-12
//