AC   PRU00236;
DC   Domain;
TR   PROSITE; PS50305; SIRTUIN; 1; level=0
XX
Names: Sirtuin catalytic domain
 Sir2 domain
Function: Sirtuins are responsible for a newly classified chemical reaction, NAD-
 dependent protein deacetylation.
XX
case <FTTag:act_site>
DE   + RecName: EC=2.3.1.286;
XX
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-
CC         ADP-D-ribose + nicotinamide + L-lysyl-[protein];
CC         Xref=Rhea:RHEA:43636, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:61930, ChEBI:CHEBI:83767;
CC         EC=2.3.1.286;
XX
GO   GO:0016407; F:acetyltransferase activity
XX
KW   NAD
KW   Transferase
end case
case <FTGroup:1>
KW   Metal-binding
KW   Zinc
end case
XX
FT   From: PS50305
FT   DOMAIN          from..to
FT                   /note="Deacetylase sirtuin-type #"
case <FTGroup:1>
FT   ACT_SITE        129
FT                   /note="Proton acceptor"
FT   Tag: act_site; Condition: H
end case
FT   BINDING         137
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         140
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         161
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: [CH]
FT   BINDING         164
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
XX
Chop: Nter=0; Cter=0;
Size: 207-331;
Related: None;
Repeats: 1;
Topology: Cytoplasmic;
Example: P06700;
Scope:
 Eukaryota
 Archaea
 Bacteria
Comments: None
XX
# Version: 16
# Last updated date: 2024-09-03
# Created date: 2003-12-12
//