AC   PRU00298;
DC   Domain;
TR   PROSITE; PS50292; PEROXIDASE_3; 1; level=0
XX
Names: Animal heme peroxidase
Function: Removal of H(2)O(2)
XX
case <FTGroup:1> and <FTGroup:2> and <FTGroup:3>
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=AH2 + H2O2 = A + 2 H2O; Xref=Rhea:RHEA:30275,
CC         ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:17499;
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC       Note=Binds 1 Ca(2+) ion per heterodimer.;
CC   -!- COFACTOR:
CC       Name=heme b; Xref=ChEBI:CHEBI:60344;
CC       Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per
CC       heterodimer.;
end case
CC   -!- SIMILARITY: Belongs to the peroxidase family.
XX
case <FTGroup:2>
DR   PROSITE; PS00435; PEROXIDASE_1; 1; trigger=no
DR   PROSITE; PS00436; PEROXIDASE_2; 1; trigger=no
end case
XX
case <FTGroup:1> and <FTGroup:2> and <FTGroup:3>
GO   GO:0016491; F:oxidoreductase activity
GO   GO:0004601; F:peroxidase activity
KW   Oxidoreductase
KW   Peroxidase
end case
case <FTGroup:1>
KW   Iron
KW   Heme
end case
case <FTGroup:3>
KW   Calcium
end case
case <FTGroup:1> or <FTGroup:3>
KW   Metal-binding
end case
case <FTTag:disulf>
KW   Disulfide bond
end case
XX
FT   From: PS50292
case <Feature:PS50292:4=C> and <Feature:PS50292:111=C>
FT   CHAIN           2..108
FT                   /note="<name> light chain"
FT   CHAIN           109..Cter
FT                   /note="<name> heavy chain"
end case
FT   BINDING         95
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /note="covalent"
FT   Group: 1; Condition: D
FT   BINDING         238
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /note="covalent"
FT   Group: 1; Condition: E
FT   ACT_SITE        96
FT                   /note="Proton acceptor"
FT   Group: 2; Condition: H
FT   SITE            235
FT                   /note="Transition state stabilizer"
FT   Group: 2; Condition: R
FT   BINDING         97
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT   Group: 3; Condition: D
FT   BINDING         164
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT   Group: 3; Condition: [ST]
FT   BINDING         166
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT   Group: 3; Condition: [FY]
FT   BINDING         168
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT   Group: 3; Condition: D
FT   BINDING         170
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT   Group: 3; Condition: [ST]
FT   BINDING         332
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT   Condition: H
FT   DISULFID        4..17
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        111..121
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        115..139
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        217..228
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        435..491
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        534..560
FT   Tag: disulf; Condition: C-x*-C
XX
Chop: Nter=0; Cter=0;
Size: 510-750;
Related: None;
Repeats: 1-6;
Topology: Undefined;
Example: P11247;
Scope:
 Eukaryota
Comments: None
XX
# Revision 1.22 2022/11/19
//