AC   PRU00340;
DC   Domain;
TR   PROSITE; PS50987; HTH_ARSR_2; 1; level=0
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Names: ArsR-type HTH domain
Function: The arsR-type HTH domain is a DNA-binding, winged helix-turn-helix
 (wHTH) domain present in transcription regulators of the arsR/smtB family,
 involved in stress-response to heavy metal ions. In this domain two distinct
 sites for metal-binding have been identified, one in helix alpha 3 and
 another in helix alpha 5, and other sites occur.
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DR   PROSITE; PS00846; HTH_ARSR_1; 1; trigger=no
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GO   GO:0003677; F:DNA binding
case <FTGroup:1>
GO   GO:0046872; F:metal ion binding
end case
GO   GO:0006355; P:regulation of DNA-templated transcription
GO   GO:0006351; P:DNA-templated transcription
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KW   DNA-binding
case <FTGroup:1> or <FTGroup:2>
KW   Metal-binding
end case
case <FTGroup:1>
KW   Metal-thiolate cluster
end case
KW   Transcription
KW   Transcription regulation
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FT   From: PS50987
FT   DOMAIN          from..to
FT                   /note="HTH arsR-type #"
FT   DNA_BIND        35..58
FT                   /note="H-T-H motif"
FT   BINDING         34
FT                   /ligand="a metal cation"
FT                   /ligand_id="ChEBI:CHEBI:25213"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: C
FT   BINDING         36
FT                   /ligand="a metal cation"
FT                   /ligand_id="ChEBI:CHEBI:25213"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: C
FT   BINDING         77
FT                   /ligand="a metal cation"
FT                   /ligand_id="ChEBI:CHEBI:25213"
FT                   /ligand_label="#2"
FT   Group: 2; Condition: D
FT   BINDING         79
FT                   /ligand="a metal cation"
FT                   /ligand_id="ChEBI:CHEBI:25213"
FT                   /ligand_label="#2"
FT   Group: 2; Condition: H
FT   BINDING         90
FT                   /ligand="a metal cation"
FT                   /ligand_id="ChEBI:CHEBI:25213"
FT                   /ligand_label="#2"
FT   Group: 2; Condition: H
FT   BINDING         93
FT                   /ligand="a metal cation"
FT                   /ligand_id="ChEBI:CHEBI:25213"
FT                   /ligand_label="#2"
FT   Group: 2; Condition: [EH]
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Warn: Replace "Metal cation" by the corresponding metal if it is known.
Chop: Nter=0; Cter=0;
Size: 68-110;
Related: None;
Repeats: 1;
Topology: Cytoplasmic;
Example: P30340;
Scope:
 Bacteria
 Archaea
Comments: None
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# Revision 1.12 2022/11/19
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