AC   PRU00379;
DC   Domain;
c?   <OC:Eukaryota>
TR   PROSITE; PS51055; ITAM_1; 0-1; level=0
c?   <OC:Viruses>
TR   PROSITE; PS51056; ITAM_2; 0-1; level=0
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Names: ITAM motif
Function: The ITAM is an immunoreceptor tyrosine-based activation motif. Phosphorylation of the two ITAM tyrosines  is  a critical event in signal transduction. This phosphorylation was found to reflect  activation  of the src family kinase Lyn and Syk.
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case <OC:Eukaryota>
DR   PROSITE; PS51055; ITAM_1; 1; trigger=no
end case
case <OC:Viruses>
DR   PROSITE; PS51056; ITAM_2; 1; trigger=no
end case
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FT   From: PS51055
FT   DOMAIN          from..to
FT                   /note="ITAM #"
FT   MOD_RES         12
FT                   /note="Phosphotyrosine"
FT   Condition: Y
FT   MOD_RES         23
FT                   /note="Phosphotyrosine"
FT   Condition: Y
FT   From: PS51056
FT   DOMAIN          from..to
FT                   /note="ITAM #"
FT   MOD_RES         5
FT                   /note="Phosphotyrosine"
FT   Condition: Y
FT   MOD_RES         18
FT                   /note="Phosphotyrosine"
FT   Condition: Y
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Chop: Nter=0; Cter=0;
Size: 24-26;
Related: none;
Repeats: 1-3;
Topology: Undefined;
Example: P04234; P28728;
Scope:
 Eukaryota
 Viruses
Comments: None
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# Revision 1.13 2019/11/21
//