AC PRU00392; DC Domain; TR PROSITE; PS51068; FPG_CAT; 1; level=0 XX Names: Formamidopyrimidine-DNA glycosylase catalytic domain Function: DNA glycosylase XX case DE + AltName: EC=3.2.2.-; DE EC=4.2.99.18; XX CC -!- FUNCTION: Involved in base excision repair of DNA damaged by oxidation CC or by mutagenic agents. Acts as DNA glycosylase that recognizes and CC removes damaged bases. CC -!- CATALYTIC ACTIVITY: CC Reaction=2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'- CC deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3- CC dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'- CC deoxyribonucleoside-DNA + H(+); Xref=Rhea:RHEA:66592, Rhea:RHEA- CC COMP:13180, Rhea:RHEA-COMP:16897, Rhea:RHEA-COMP:17067, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:136412, ChEBI:CHEBI:157695, CC ChEBI:CHEBI:167181; EC=4.2.99.18; CC -!- SIMILARITY: Belongs to the FPG family. end case XX case GO GO:0006974; P:DNA damage response GO GO:0006281; P:DNA repair GO GO:0003677; F:DNA binding GO GO:0016798; F:hydrolase activity, acting on glycosyl bonds GO GO:0016787; F:hydrolase activity GO GO:0016829; F:lyase activity GO GO:0003824; F:catalytic activity KW DNA damage KW DNA repair KW DNA-binding KW Glycosidase KW Hydrolase KW Lyase KW Multifunctional enzyme end case XX FT From: PS51068 FT ACT_SITE 1 FT /note="Schiff-base intermediate with DNA" FT Group: 1; Condition: P FT ACT_SITE 2 FT /note="Proton donor" FT Group: 1; Condition: E FT ACT_SITE 57 FT /note="Proton donor (in beta-elimination)" FT Group: 1; Condition: K XX Chop: Nter=0; Cter=0; Size: 70-150; Related: None; Repeats: 1; Topology: Undefined; Example: P05523; Scope: Eukaryota Bacteria Archaea Comments: None XX # Revision 1.17 2024/01/11 //