AC   PRU00399;
DC   Domain;
TR   PROSITE; PS51062; RUNT; 1; level=0
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Names: Runt domain
Function: The Runt domain confers DNA binding ability to the consensus core
 PyGPyGGT and mediates the interaction of mammalian RUNX proteins with the
 beta-subunit, designated core-binding factor beta (CBFbeta), which increases
 the DNA binding affinity of the heterodimer.
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CC   -!- SUBCELLULAR LOCATION: Nucleus.
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GO   GO:0003677; F:DNA binding
GO   GO:0005634; C:nucleus
GO   GO:0006355; P:regulation of DNA-templated transcription
GO   GO:0006351; P:DNA-templated transcription
case <FTGroup:1> or <FTGroup:2>
KW   Chloride
end case
KW   DNA-binding
KW   Nucleus
KW   Transcription
KW   Transcription regulation
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FT   From: PS51062
FT   DOMAIN          from..to
FT                   /note="Runt #"
FT   REGION          31..35
FT                   /note="Interaction with DNA"
FT   REGION          86..94
FT                   /note="Interaction with DNA"
FT   REGION          119..128
FT                   /note="Interaction with DNA"
FT   BINDING         63
FT                   /ligand="chloride"
FT                   /ligand_id="ChEBI:CHEBI:17996"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: N
FT   BINDING         67
FT                   /ligand="chloride"
FT                   /ligand_id="ChEBI:CHEBI:17996"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: E
FT   BINDING         90
FT                   /ligand="chloride"
FT                   /ligand_id="ChEBI:CHEBI:17996"
FT                   /ligand_label="#2"
FT   Group: 2; Condition: R
FT   BINDING         121
FT                   /ligand="chloride"
FT                   /ligand_id="ChEBI:CHEBI:17996"
FT                   /ligand_label="#2"
FT   Group: 2; Condition: V
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Chop: Nter=0; Cter=0;
Size: 125-135;
Related: None;
Repeats: 1;
Topology: Not cytoplasmic;
Example: Q01196;
Scope:
 Eukaryota; Metazoa
Comments: None
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# Revision 1.11 2022/11/19
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