AC PRU00545; DC Domain; TR PROSITE; PS51200; SHORT_SCORPION_CHLORIDE; 1; level=0 XX Names: Scorpion short toxin chloride channel inhibitor subfamily Function: Short scorpion toxin chloride channel inhibitors are short-chain neurotoxins (SCNs), which block small-conductance chloride channels. They are 30-40-residue long and contain four intramolecular disulfide bridges, which have been assigned as C1-C4, C2-C6, C3-C7 and C5-C8. XX CC -!- FUNCTION: Probable chloride channel ligand, which blocks small- CC conductance chloride channels. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Chloride CC channel inhibitor family. XX GO GO:0019869; F:chloride channel inhibitor activity GO GO:0008200; F:ion channel inhibitor activity XX KW Secreted KW Voltage-gated chloride channel impairing toxin KW Chloride channel impairing toxin KW Ion channel impairing toxin KW Neurotoxin KW Toxin case KW Disulfide bond end case XX FT From: PS51200 FT DISULFID 1..18 FT Tag: disulf; Condition: C-x*-C FT DISULFID 4..25 FT Tag: disulf; Condition: C-x*-C FT DISULFID 15..30 FT Tag: disulf; Condition: C-x*-C FT DISULFID 19..32 FT Tag: disulf; Condition: C-x*-C XX Chop: Nter=0; Cter=0; Size: 20-35; Related: None; Repeats: 1; Topology: Undefined; Example: P15229; Scope: Eukaryota; Metazoa; Arachnida; Scorpiones Comments: None XX # Revision 1.10 2021/06/03 //