AC   PRU00660;
DC   Domain;
TR   PROSITE; PS51330; DHFR_2; 1; level=0
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Names: Dihydrofolate reductase (DHFR) domain
Function: Dihydrofolate reductases (DHFRs) (EC 1.5.1.3) are ubiquitous enzymes
 which catalyze the NADPH-linked reduction of 7,8-dihydrofolate to 5,6,7,8-
 tetrahydrofolate.
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DE   + RecName: EC=1.5.1.3;
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CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate +
CC         H(+) + NADPH; Xref=Rhea:RHEA:15009, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57451, ChEBI:CHEBI:57453, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349; EC=1.5.1.3;
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DR   PROSITE; PS00075; DHFR_1; 1; trigger=no
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GO   GO:0016491; F:oxidoreductase activity
GO   GO:0004146; F:dihydrofolate reductase activity
GO   GO:0050661; F:NADP binding
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KW   NADP
KW   Oxidoreductase
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FT   From: PS51330
FT   DOMAIN          from..to
FT                   /note="DHFR #"
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Chop: Nter=0; Cter=0;
Size: 145-257;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: Q5V3R2;
Scope:
 Bacteria
 Eukaryota
 Viruses
 Archaea
Comments: None;
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# Revision 1.7 2021/01/11
//