AC   PRU00679;
DC   Domain;
TR   PROSITE; PS51347; PHOSPHOTRIESTERASE_2; 1; level=0
XX
Names: Phosphotriesterase family
Function: The enzyme phosphotriesterase (EC 3.1.8.1) (PTE) (also known as
 parathion hydrolase) belongs to a family of enzymes that possess a binuclear
 zinc metal center at their active site. The two zinc ions are coordinated by
 six different residues, four of which being histidines.
XX
case <FTGroup:1> and <FTGroup:2>
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 2 Zn(2+) ions per subunit.;
end case
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Phosphotriesterase family.
XX
case <FTGroup:1>
DR   PROSITE; PS01322; PHOSPHOTRIESTERASE_1; 1; trigger=no
end case
XX
case <FTGroup:1> or <FTGroup:2>
GO   GO:0016787; F:hydrolase activity
GO   GO:0046872; F:metal ion binding
GO   GO:0008270; F:zinc ion binding
XX
KW   Hydrolase
KW   Metal-binding
KW   Zinc
end case
XX
FT   From: PS51347
FT   BINDING         21
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: H
FT   BINDING         23
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: H
FT   BINDING         142
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT                   /note="via carbamate group"
FT   Group: 1; Condition: [KE]
FT   BINDING         142
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#2"
FT                   /note="via carbamate group"
FT   Group: 2; Condition: [KE]
FT   BINDING         175
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#2"
FT   Group: 2; Condition: H
FT   BINDING         204
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#2"
FT   Group: 2; Condition: H
FT   BINDING         263
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: D
FT   MOD_RES         142
FT                   /note="N6-carboxylysine"
FT   Condition: K
XX
Chop: Nter=0; Cter=0;
Size: 280-360;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: P0A433;
Scope:
 Eukaryota
 Bacteria
Comments: None
XX
# Revision 1.9 2022/11/19
//