AC   PRU00680;
DC   Domain;
TR   PROSITE; PS51348; GLYCOSYL_HYDROL_F22_2; 1; level=0
XX
Names: Glycosyl hydrolases family 22 (GH22) domain
Function: Alpha-lactalbumin, a regulatory protein in milk, and lysozyme
 (EC 3.2.1.17) C (chicken type), which acts as a bacteriolytic enzyme, belong
 to a family of proteins with eight conserved cysteines that form four
 disulfide bonds. Alpha-lactalbumin lacks the enzymatic activity and the
 corresponding Glu and Asp residues. Alpha-lactalbumin binds a calcium ion,
 while most lysozyme C do not bind calcium.
XX
case <FTGroup:1>
DE   + AltName: Full=lysozyme C;
DE            EC=3.2.1.17;
DE   AltName: Full=1,4-beta-N-acetylmuramidase C;
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CC   -!- FUNCTION: Lysozymes have primarily a bacteriolytic function; those in
CC       tissues and body fluids are associated with the monocyte-macrophage
CC       system and enhance the activity of immunoagents.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic
CC         acid and N-acetyl-D-glucosamine residues in a peptidoglycan and
CC         between N-acetyl-D-glucosamine residues in chitodextrins.;
CC         EC=3.2.1.17;
end case
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 22 family.
XX
DR   PROSITE; PS00128; GLYCOSYL_HYDROL_F22_1; 1; trigger=no
XX
case <FTGroup:1>
GO   GO:0003824; F:catalytic activity
GO   GO:0019835; P:cytolysis
GO   GO:0042742; P:defense response to bacterium
GO   GO:0016798; F:hydrolase activity, acting on glycosyl bonds
GO   GO:0008152; P:metabolic process
GO   GO:0016787; F:hydrolase activity
end case
case <Feature:PS51348:85=D> and <Feature:PS51348:90-91=D-D>
GO   GO:0005509; F:calcium ion binding
end case
XX
case <FTGroup:1>
KW   Antimicrobial
KW   Bacteriolytic enzyme
KW   Glycosidase
KW   Hydrolase
end case
case <Feature:PS51348:85=D> and <Feature:PS51348:90-91=D-D>
KW   Calcium
end case
case <FTTag:disulf>
KW   Disulfide bond
end case
XX
FT   From: PS51348
FT   DOMAIN          from..to
FT                   /note="C-type lysozyme #"
FT   ACT_SITE        35
FT   Group: 1; Condition: E
FT   ACT_SITE        52
FT   Group: 1; Condition: D
case <Feature:PS51348:85=D> and <Feature:PS51348:90-91=D-D>
FT   BINDING         82
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="#1"
FT   Tag: binds; Condition: [HCUEDKQNMYWSTRX]
FT   BINDING         85
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="#1"
FT   Tag: binds; Condition: [HCUEDKQNMYWSTRX]
FT   BINDING         87
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="#1"
FT   Tag: binds; Condition: [HCUEDKQNMYWSTRX]
FT   BINDING         90
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="#1"
FT   Tag: binds; Condition: [HCUEDKQNMYWSTRX]
FT   BINDING         91
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="#1"
FT   Tag: binds; Condition: [HCUEDKQNMYWSTRX]
end case
FT   DISULFID        6..125
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        30..114
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        64..80
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        76..94
FT   Tag: disulf; Condition: C-x*-C
XX
Chop: Nter=0; Cter=0;
Size: 110-140;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: Q659U0;
Scope:
 Eukaryota; Metazoa
Comments: None
XX
# Revision 1.12 2022/11/19
//