AC PRU00700; DC Domain; TR PROSITE; PS51368; UREASE_3; 1; level=0 XX Names: Urease domain Function: Urease (EC 3.5.1.5) is a nickel-binding enzyme that catalyzes the hydrolysis of urea to carbon dioxide and ammonia. The urease domain forms an (alpha beta)(8) barrel structure that binds two nickel ions and with a histidine that is catalytically involved. XX case and and and not and not DE + AltName: Full=Urease; DE EC=3.5.1.5; DE AltName: Full=Urea amidohydrolase; end case XX case and and CC -!- CATALYTIC ACTIVITY: CC Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+); Xref=Rhea:RHEA:20557, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16199, CC ChEBI:CHEBI:16526, ChEBI:CHEBI:28938; EC=3.5.1.5; end case case or CC -!- COFACTOR: CC Name=Ni(2+); Xref=ChEBI:CHEBI:49786; CC Note=Binds #(nickel,ion) per subunit.; end case case CC -!- SUBCELLULAR LOCATION: Cytoplasm. end case case and CC -!- SIMILARITY: In the C-terminal section; belongs to the metallo-dependent CC hydrolases superfamily. Urease alpha subunit family. else CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily. CC Urease alpha subunit family. end case XX case and DR PROSITE; PS01120; UREASE_1; 1; trigger=no end case case DR PROSITE; PS00145; UREASE_2; 1; trigger=no end case XX case GO GO:0016787; F:hydrolase activity end case case or GO GO:0046872; F:metal ion binding GO GO:0016151; F:nickel cation binding end case case GO GO:0005737; C:cytoplasm end case XX case KW Cytoplasm end case case KW Hydrolase end case case or KW Metal-binding KW Nickel end case XX FT From: PS51368 FT DOMAIN from..to FT /note="Urease #" FT ACT_SITE 192 FT /note="Proton donor" FT Condition: H FT METAL 6 FT /note="Nickel #2" FT Group: 2; Condition: H FT METAL 8 FT /note="Nickel #2" FT Group: 2; Condition: H FT METAL 89 FT /note="Nickel #1; via carbamate group" FT Group: 1; Condition: K FT METAL 89 FT /note="Nickel #2; via carbamate group" FT Group: 2; Condition: K FT METAL 118 FT /note="Nickel #1" FT Group: 1; Condition: H FT METAL 144 FT /note="Nickel #1" FT Group: 1; Condition: H FT METAL 232 FT /note="Nickel #2" FT Group: 2; Condition: D FT BINDING 91 FT /note="Substrate" FT Condition: H XX Chop: Nter=0; Cter=0; Size: 420-470; Related: None; Repeats: 1; Topology: Undefined; Example: Q5KCQ6; Scope: Eukaryota Bacteria Archaea Comments: None XX # Revision 1.17 2019/11/21 //