AC   PRU00706;
DC   Domain;
TR   PROSITE; PS51374; NDPK_LIKE; 1; level=0
XX
Names: Nucleoside diphosphate kinase (NDK)-like domain
Function: All Nme enzymes possess at least one nucleoside diphosphate kinase
 (NDK)-like domain of ~150 amino acids.
XX
case <FTGroup:1> and <FTTag:act_site>
DE   + AltName: Full=Nucleoside diphosphate kinase;
DE            Short=NDK;
DE            Short=NDP kinase {ECO:0000255|HAMAP-Rule:MF_00451};
DE            EC=2.7.4.6;
CC   -!- CATALYTIC ACTIVITY: Reaction=a 2'-deoxyribonucleoside 5'-
CC       diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate +
CC       ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560,
CC       ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=2.7.4.6;
CC   -!- CATALYTIC ACTIVITY: Reaction=a ribonucleoside 5'-diphosphate + ATP
CC       = a ribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:18113,
CC       ChEBI:CHEBI:30616, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557,
CC       ChEBI:CHEBI:456216; EC=2.7.4.6;
CC   -!- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
end case
CC   -!- SIMILARITY: Belongs to the NDK family.
XX
case <FTGroup:1> and <FTTag:act_site>
DR   PROSITE; PS00469; NDPK; 1; trigger=no
XX
GO   GO:0004550; F:nucleoside diphosphate kinase activity
GO   GO:0006241; P:CTP biosynthetic process
GO   GO:0005524; F:ATP binding
GO   GO:0006228; P:UTP biosynthetic process
GO   GO:0006183; P:GTP biosynthetic process
GO   GO:0016310; P:phosphorylation
GO   GO:0046872; F:metal ion binding
XX
KW   Kinase
KW   Transferase
KW   Nucleotide-binding
KW   ATP-binding
KW   Magnesium
KW   Metal-binding
KW   Nucleotide metabolism
KW   Phosphoprotein
end case
XX
FT   From: PS51374
FT   DOMAIN          from..to
FT                   /note="NDPK-like #"
case <FTGroup:1>
FT   ACT_SITE        114
FT                   /note="Pros-phosphohistidine intermediate"
FT   Tag: act_site; Condition: H
end case
FT   BINDING         8
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Group: 1; Condition: K
FT   BINDING         56
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Group: 1; Condition: F
FT   BINDING         84
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Group: 1; Condition: R
FT   BINDING         90
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Group: 1; Condition: T
FT   BINDING         101
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Group: 1; Condition: R
FT   BINDING         111
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Group: 1; Condition: N
XX
Chop: Nter=0; Cter=0;
Size: 21-180;
Related: None;
Repeats: 1-3;
Topology: Undefined;
Example: C3LT09;
Scope:
 Bacteria
 Eukaryota
 Archaea
 Viruses; Mimivirus bradfordmassiliense
Comments: None;
XX
# Revision 1.1 2023/12/20
//