AC   PRU00736;
DC   Domain;
TR   PROSITE; PS51403; NC1_IV; 1; level=0
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Names: Collagen IV carboxyl-terminal non-collagenous (NC1) domain
Function: Each type IV chain contains a long triple-helical collagenous domain
 flanked by a short 7S domain of 25 residues and a globular non-collagenous
 NC1 domain of ~230 residues at the N- and C-terminus, respectively.
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CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix, basement membrane.
CC   -!- DOMAIN: Alpha chains of type IV collagen have a non-collagenous domain
CC       (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats
CC       in the long central triple-helical domain (which may cause flexibility
CC       in the triple helix), and a short N-terminal triple-helical 7S domain.
CC   -!- PTM: Prolines at the third position of the tripeptide repeating unit
CC       (G-X-Y) are hydroxylated in some or all of the chains.
CC   -!- PTM: Type IV collagens contain numerous cysteine residues which are
CC       involved in inter- and intramolecular disulfide bonding. 12 of these,
CC       located in the NC1 domain, are conserved in all known type IV
CC       collagens.
CC   -!- SIMILARITY: Belongs to the type IV collagen family.
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GO   GO:0005604; C:basement membrane
GO   GO:0031012; C:extracellular matrix
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KW   Basement membrane
KW   Collagen
KW   Extracellular matrix
KW   Secreted
case <FTTag:disulf>
KW   Disulfide bond
end case
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FT   From: PS51403
FT   DOMAIN          from..to
FT                   /note="Collagen IV NC1 #"
FT   DISULFID        16..106
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        49..103
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        61..67
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        125..220
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        159..217
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        171..177
FT   Tag: disulf; Condition: C-x*-C
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Chop: Nter=0; Cter=0;
Size: 220-230;
Related: None;
Repeats: 1;
Topology: Not cytoplasmic;
Example: P02462;
Scope:
 Eukaryota; Metazoa
Comments: None;
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# Revision 1.10 2019/11/21
//