AC   PRU00742;
DC   Domain;
TR   PROSITE; PS51409; ARGINASE_2; 1; level=0
XX
Names: Arginase family
 ureohydrolase superfamily
Function: Arginase family proteins are ureohydrolases with important roles in
 arginine/agmatine metabolism, the urea cycle, histidine degradation, and
 other pathways. The family includes arginase and related enzymes of ~300
 amino acids that typically contain two manganese ions in the active site.
XX
case <Feature:PS51409:96=[HN]> and <Feature:PS51409:120=D> and <Feature:PS51409:122=H> and <Feature:PS51409:124=D> and <Feature:PS51409:213=[DC]> and <Feature:PS51409:215=D>
DE   + RecName: EC=3.5.3.-;
end case
XX
case <Feature:PS51409:96=[HN]> and <Feature:PS51409:120=D> and <Feature:PS51409:122=H> and <Feature:PS51409:124=D> and <Feature:PS51409:213=[DC]> and <Feature:PS51409:215=D>
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC       Note=Binds 2 manganese ions per subunit.;
else case <Feature:PS51409:96=[HN]> or <Feature:PS51409:120=D> or <Feature:PS51409:122=H> or <Feature:PS51409:124=D> or <Feature:PS51409:213=[DC]> or <Feature:PS51409:215=D>
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
end case
CC   -!- SIMILARITY: Belongs to the arginase family.
XX
case <Feature:PS51409:213=[DC]> and <Feature:PS51409:215=D>
DR   PROSITE; PS01053; ARGINASE_1; 1; trigger=no
end case
XX
case <Feature:PS51409:96=[HN]> or <Feature:PS51409:120=D> or <Feature:PS51409:122=H> or <Feature:PS51409:124=D> or <Feature:PS51409:213=[DC]> or <Feature:PS51409:215=D>
GO   GO:0016787; F:hydrolase activity
GO   GO:0030145; F:manganese ion binding
GO   GO:0046872; F:metal ion binding
XX
KW   Hydrolase
KW   Manganese
KW   Metal-binding
end case
XX
FT   From: PS51409
FT   BINDING         96
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="#1"
FT   Condition: [HN]
FT   BINDING         120
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="#1"
FT   Condition: D
FT   BINDING         120
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="#2"
FT   Condition: D
FT   BINDING         122
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="#2"
FT   Condition: H
FT   BINDING         124
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="#1"
FT   Condition: D
FT   BINDING         213
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="#1"
FT   Condition: [DC]
FT   BINDING         213
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="#2"
FT   Condition: [DC]
FT   BINDING         215
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="#2"
FT   Condition: D
XX
Chop: Nter=0; Cter=0;
Size: 260-350;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: Q9HQD7; P46637;
Scope:
 Eukaryota
 Bacteria
 Archaea
Comments: None
XX
# Revision 1.8 2022/11/19
//