AC   PRU00763;
DC   Domain;
TR   PROSITE; PS51432; AP_NUCLEASE_F2_4; 1; level=0
XX
Names: AP endonucleases family 2
Function: Endonuclease 4 related enzymes play a role in DNA repair. These
 nucleases cleave phosphodiester bonds at apurinic or apyrimidinic sites (AP
 sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate
 residues.
XX
case <OC:Bacteria> or <OC:Archaea> or <OC:Amoebozoa>
DE   AltName: Full=Probable endonuclease 4;
DE            EC=3.1.21.2;
DE   AltName: Full=Endonuclease IV;
DE   AltName: Full=Endodeoxyribonuclease IV;
else case <OC:Fungi> or <OC:Nematoda> or <OC:Viruses>
XX
DE   + RecName: EC=3.1.21.-;
end case
XX
case <OC:Bacteria> or <OC:Archaea> or <OC:Amoebozoa>
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphooligonucleotide end-
CC         products.; EC=3.1.21.2;
end case
XX
case <OC:Eukaryota>
CC   -!- SUBCELLULAR LOCATION: Nucleus.
end case
case <FTGroup:1> and <FTGroup:2> and <FTGroup:3>
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 3 Zn(2+) ions.;
else case <FTGroup:1> or <FTGroup:2> or <FTGroup:3>
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
end case
CC   -!- SIMILARITY: Belongs to the AP endonuclease 2 family.
XX
case <Feature:PS51432:67=H>
DR   PROSITE; PS00729; AP_NUCLEASE_F2_1; 1; trigger=no
end case
case <Feature:PS51432:177=D> and <Feature:PS51432:180=H>
DR   PROSITE; PS00730; AP_NUCLEASE_F2_2; 1; trigger=no
end case
case <Feature:PS51432:214=H> and <Feature:PS51432:227=D> and <Feature:PS51432:229=H>
DR   PROSITE; PS00731; AP_NUCLEASE_F2_3; 1; trigger=no
end case
XX
GO   GO:0006974; P:DNA damage response
GO   GO:0006281; P:DNA repair
GO   GO:0046872; F:metal ion binding
GO   GO:0008270; F:zinc ion binding
GO   GO:0003677; F:DNA binding
case <OC:Bacteria> or <OC:Archaea> or <OC:Amoebozoa> or <OC:Viruses>
GO   GO:0008833; F:deoxyribonuclease IV (phage-T4-induced) activity
GO   GO:0004519; F:endonuclease activity
GO   GO:0004518; F:nuclease activity
GO   GO:0016787; F:hydrolase activity
else case <OC:Fungi> or <OC:Nematoda>
GO   GO:0003906; F:DNA-(apurinic or apyrimidinic site) endonuclease activity
end case
case <OC:Eukaryota>
GO   GO:0005634; C:nucleus
else case <OC:Bacteria> or <OC:Archaea>
GO   GO:0005737; C:cytoplasm
end case
XX
KW   DNA damage
KW   DNA repair
KW   Hydrolase
KW   Endonuclease
KW   Nuclease
case <FTGroup:1> or <FTGroup:2> or <FTGroup:3>
KW   Metal-binding
KW   Zinc
end case
case <OC:Eukaryota>
KW   Nucleus
end case
XX
FT   From: PS51432
FT   BINDING         67
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT   Group: 1; Condition: H
FT   BINDING         107
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT   Group: 1; Condition: H
FT   BINDING         143
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT   Group: 1; Condition: E
FT   BINDING         143
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT   Group: 2; Condition: E
FT   BINDING         177
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT   Group: 2; Condition: D
FT   BINDING         180
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="3"
FT   Group: 3; Condition: H
FT   BINDING         214
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT   Group: 2; Condition: H
FT   BINDING         227
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="3"
FT   Group: 3; Condition: D
FT   BINDING         229
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="3"
FT   Group: 3; Condition: H
FT   BINDING         259
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT   Group: 2; Condition: E
XX
Chop: Nter=0; Cter=0;
Size: 240-305;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: A4IR02; Q966U0; Q5UPY4; Q10002;
Scope:
 Bacteria
 Archaea
 Eukaryota
 Viruses
Comments: None;
XX
# Revision 1.12 2023/02/13
//