AC PRU00764; DC Domain; TR PROSITE; PS51435; AP_NUCLEASE_F1_4; 1; level=0 XX Names: AP endonucleases family 1 Function: Exonuclease III and AP endonuclease 1 related enzymes play a role in DNA repair. These nucleases cleave phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. XX case DE AltName: Full=DNA-(apurinic or apyrimidinic site) endonuclease; DE EC=3.1.-.-; else case DE AltName: Full=Exodeoxyribonuclease III; DE Short=Exonuclease III; DE Short=EXO III; DE EC=3.1.11.2; end case XX case CC -!- SUBCELLULAR LOCATION: Nucleus. else case CC -!- CATALYTIC ACTIVITY: CC Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield CC nucleoside 5'-phosphates.; EC=3.1.11.2; CC -!- SUBCELLULAR LOCATION: Cytoplasm. end case CC -!- SIMILARITY: Belongs to the DNA repair enzymes AP/exoA family. XX case DR PROSITE; PS00726; AP_NUCLEASE_F1_1; 1; trigger=no end case DR PROSITE; PS00727; AP_NUCLEASE_F1_2; 1; trigger=no DR PROSITE; PS00728; AP_NUCLEASE_F1_3; 1; trigger=no XX GO GO:0003677; F:DNA binding GO GO:0004519; F:endonuclease activity GO GO:0006281; P:DNA repair case GO GO:0003906; F:DNA-(apurinic or apyrimidinic site) endonuclease activity GO GO:0005634; C:nucleus else case GO GO:0000287; F:magnesium ion binding GO GO:0008311; F:double-stranded DNA 3'-5' DNA exonuclease activity GO GO:0005737; C:cytoplasm end case XX KW DNA damage KW DNA repair KW Hydrolase KW Metal-binding KW Nuclease case KW Endonuclease KW Nucleus else case KW Cytoplasm KW Exonuclease KW Magnesium end case XX FT From: PS51435 FT ACT_SITE 258 FT /note="Proton acceptor" FT Condition: H FT BINDING 7 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT Condition: N FT BINDING 40 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT Condition: E FT BINDING 158 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT Condition: D FT BINDING 160 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT Condition: N FT BINDING 257 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT Condition: D FT BINDING 258 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT Condition: H XX Chop: Nter=0; Cter=0; Size: 230-370; Related: None; Repeats: 1; Topology: Undefined; Example: P28352; P44318; Scope: Eukaryota Bacteria Comments: None; XX # Revision 1.12 2023/02/13 //