AC   PRU00764;
DC   Domain;
TR   PROSITE; PS51435; AP_NUCLEASE_F1_4; 1; level=0
XX
Names: AP endonucleases family 1
Function: Exonuclease III and AP endonuclease 1 related enzymes play a role
 in DNA repair. These nucleases cleave phosphodiester bonds at apurinic or
 apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free
 deoxyribose 5-phosphate residues.
XX
case <OC:Eukaryota>
DE   AltName: Full=DNA-(apurinic or apyrimidinic site) endonuclease;
DE            EC=3.1.-.-;
else case <OC:Bacteria>
DE   AltName: Full=Exodeoxyribonuclease III;
DE            Short=Exonuclease III;
DE            Short=EXO III;
DE            EC=3.1.11.2;
end case
XX
case <OC:Eukaryota>
CC   -!- SUBCELLULAR LOCATION: Nucleus.
else case <OC:Bacteria>
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC         nucleoside 5'-phosphates.; EC=3.1.11.2;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
end case
CC   -!- SIMILARITY: Belongs to the DNA repair enzymes AP/exoA family.
XX
case <Feature:PS51435:40=E>
DR   PROSITE; PS00726; AP_NUCLEASE_F1_1; 1; trigger=no
end case
DR   PROSITE; PS00727; AP_NUCLEASE_F1_2; 1; trigger=no
DR   PROSITE; PS00728; AP_NUCLEASE_F1_3; 1; trigger=no
XX
GO   GO:0003677; F:DNA binding
GO   GO:0004519; F:endonuclease activity
GO   GO:0006281; P:DNA repair
case <OC:Eukaryota>
GO   GO:0003906; F:DNA-(apurinic or apyrimidinic site) endonuclease activity
GO   GO:0005634; C:nucleus
else case <OC:Bacteria>
GO   GO:0000287; F:magnesium ion binding
GO   GO:0008853; F:exodeoxyribonuclease III activity
GO   GO:0005737; C:cytoplasm
end case
XX
KW   DNA damage
KW   DNA repair
KW   Hydrolase
KW   Metal-binding
KW   Nuclease
case <OC:Eukaryota>
KW   Endonuclease
KW   Nucleus
else case <OC:Bacteria>
KW   Cytoplasm
KW   Exonuclease
KW   Magnesium
end case
XX
FT   From: PS51435
FT   ACT_SITE        258
FT                   /note="Proton acceptor"
FT   Condition: H
FT   METAL           7
FT                   /note="Magnesium"
FT   Condition: N
FT   METAL           40
FT                   /note="Magnesium"
FT   Condition: E
FT   METAL           158
FT                   /note="Magnesium"
FT   Condition: D
FT   METAL           160
FT                   /note="Magnesium"
FT   Condition: N
FT   METAL           257
FT                   /note="Magnesium"
FT   Condition: D
FT   METAL           258
FT                   /note="Magnesium"
FT   Condition: H
XX
Chop: Nter=0; Cter=0;
Size: 230-370;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: P28352; P44318;
Scope:
 Eukaryota
 Bacteria
Comments: None;
XX
# Revision 1.9 2022/02/11
//