AC   PRU00772;
DC   Domain;
TR   PROSITE; PS51442; M_PRO; 1; level=0
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Names: Coronavirus main protease (M-pro) domain
 3C-like proteinase (3CL-pro)
 peptidase family C30
Function: It is a viral cysteine proteinase wich mediates most maturation
 cleavage events within the precursor polyprotein.
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case <FTGroup:1>
CC   -!- FUNCTION: The main proteinase 3CL-PRO is responsible for the majority
CC       of cleavages as it cleaves the C-terminus of replicase polyprotein at
CC       11 sites. Recognizes substrates containing the core sequence [ILMVF]-
CC       Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-
CC       Gln-CMK.
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GO   GO:0019082; P:viral protein processing
GO   GO:0006508; P:proteolysis
GO   GO:0008233; F:peptidase activity
GO   GO:0016787; F:hydrolase activity
GO   GO:0008234; F:cysteine-type peptidase activity
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KW   Hydrolase
KW   Protease
KW   Thiol protease
end case
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FT   From: PS51442
FT   DOMAIN          from..to
FT                   /note="Peptidase C30 #"
FT   ACT_SITE        41
FT                   /note="For 3CL-PRO activity"
FT   Group: 1; Condition: H
FT   ACT_SITE        144
FT                   /note="For 3CL-PRO activity"
FT   Group: 1; Condition: C
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Chop: Nter=0; Cter=0;
Size: 292-317;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: P0C6Y1;
Scope:
 Viruses; Coronavirinae
Comments: None;
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# Revision 1.5 2019/11/21
//